Three of the 11 authors of the 2005 Journal of Cell Science paper being retracted — David Latchman, Richard Knight, and Anastasis Stephanou — were authors of a Journal of Biological Chemistry paper retracted in January. Stephanou takes the blame for the “errors” which felled the Journal of Cell Science paper, about how a tumor suppressor responds to DNA damage.
Here’s the notice for “STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage:”
We were recently made aware of errors in our paper, which include misrepresentation of western blot data in Figs 4, 5 and 6 as detailed below. The misuse and re-use of western blot bands breaches the editorial policy of Journal of Cell Science, and so we must retract this article. The corresponding author, A.S., regrets the inappropriate figure manipulations of which the co-authors were completely unaware. We deeply regret that the majority of sound research presented in the rest of the paper has been invalidated in this manner, and the concern this will cause to the research community. The co-authors are repeating the affected experiments to determine whether the overall conclusions of the paper remain valid.
1. Fig. 4A, Panel B MDC1 Input lane and Panel A p53BP1 Input lane are the same (flipped horizontally).
2. Fig. 5A (pNBS1), Fig. 5B ATM and Fig. 5G (p53) blots are the same.
3. Fig. 5A (Chk2), Fig. 5C (pChk2) and Fig. 5G (Chk2) blots are the same.
4. Fig. 5B actin and Fig. 5E actin blots are the same.
5. Fig. 6A ATM and pChk2 are the same blot.
6. Fig. 6C and Fig. 6E actin blots are the same.
The paper has been cited 48 times, according to Thomson Scientific’s Web of Knowledge.
Commenters at PubPeer, where more than 25 papers by Latchman are the subject of scrutiny, had pointed out a number of potential issues with figures 5 and 6 beginning in September. University College London (UCL) told us in January that an investigation was underway and that
Some errors have been identified in eight publications, and appropriate retractions have taken place.
Latchman maintains a lab at UCL, but is also master of Birkbeck, University of London.
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