jbc retractions – Retraction Watch

Author says ‘misguided efforts for the ideal western blot led to the withdrawal of these studies’

A figure marked up by Elisabeth Bik on PubPeer

The Journal of Biological Chemistry has retracted two papers by a group from the University of Toronto over what the leader of the research says were “misguided efforts” by a co-author to make the perfect Western blot.

The retractions are among a batch of seven recent removals by the journal for image issues, some of which were flagged on PubPeer.

Two of the papers, which date back to 2004, come from one group, two from another and two from a third. The seventh is a stand-alone for a group with a history of problematic articles.

Cleveland Clinic heart researchers earn two expressions of concern

A team of heart researchers at Cleveland Clinic in Ohio has received expressions of concern for two papers in the Journal of Biological Chemistry, which says the images in the articles appear suspect.

The papers, both of which appeared in 2004, come from the lab of Subha Sen, a highly-funded scientist who has received millions in NIH grants over the past decade. Sen’s work also has drawn scrutiny on PubPeer, with comments cropping up on the site roughly three years ago for many of her papers.

In 2016, Sen’s group retracted a 2009 article in JBC titled “A unique microRNA profile in end-stage heart failure indicates alterations in specific cardiovascular signaling networks.” According to the notice:

Georgia State researcher up to nine retractions disagrees with the journal

A prominent researcher at Georgia State University who had two papers retracted and eight subjected to expressions of concern for problematic images last year is now up to nine retractions.

Ming-Hui Zou is the common author on all nine retracted papers, which were published in the Journal of Biological Chemistry from 2003 and 2010. Of the eight papers originally subjected to expressions of concern, seven have been retracted, and one has been updated to a correction.

Here is a typical retraction notice, for “Nicotine-induced activation of AMP-activated protein kinase inhibits fatty acid synthase in 3T3L1 adipocytes: A role for oxidant stress,” referring to image duplication, and an offer by the authors to “publish an amended figure or to repeat the experiments,” which the journal declined:

Prominent cancer researcher loses nine papers, making 10

Andrew Dannenberg (credit Patricia Kuharic)

The Journal of Biological Chemistry (JBC) has retracted nine papers in bulk by a group of cancer researchers in New York led by the prominent scientist Andrew Dannenberg.

The work of Dannenberg’s group at Weill Cornell — and the figures in particular — has been the subject of scrutiny on PubPeer for more than two years.

The group also lost an article more than a decade ago in The Lancet, bringing their total so far to 10. Cancer Discovery subjected a paper to an expression of concern in August. Much of the tainted work was funded by grants from the U.S. government, as well as from funding authorities in other countries.

According to the notice for 2014’s “p53 protein regulates Hsp90 ATPase activity and thereby Wnt signaling by modulating Aha1 expression“:

Award-winning researcher in India retracts two papers, corrects three

Kithiganahalli Narayanaswamy Balaji, a professor at the Indian Institute of Science in Bangalore, has retracted two papers and corrected three for duplication of images.

Balaji, who won the 2011 Shanti Swarup Bhatnagar Prize from India’s Council of Scientific & Industrial Research (CSIR) “for outstanding contributions to science and technology,” is last author of the five papers, which were published in the Journal of Biological Chemistry (JBC) from 2008 to 2015.

The authors take responsibility for what they call “inadvertent mistakes.” The retraction notice for “Pathogen-specific TLR2 protein activation programs macrophages to induce Wnt-β-catenin signaling,” for example, concludes as follows:

Northwestern researcher has four more papers retracted, making five

A pathologist in Chicago has lost five papers for image manipulation and other problems.

The first retraction for Yashpal Kanwar, of the Feinberg School of Medicine at Northwestern University, appeared in 2013, for a review article published earlier that year in the American Journal of Physiology Renal Physiology. According to the notice:

UCLA group has three papers retracted

The Journal of Biological Chemistry has retracted three papers by a group from the University of California, Los Angeles, citing problems with the figures.

Two of the papers, published in 2002, 2004 and 2009, have the same last author, Mark H. Doolittle, who is the first author of the most recent article. Doolittle, who appears to be a highly talented woodworker, has left UCLA and did not respond to a request for comment.

The retraction notice for the 2002 paper, “Maturation of lipoprotein lipase in the endoplasmic reticulum: Concurrent formation of functional dimers and inactive aggregates,” states:

Georgia State researcher has two papers retracted, eight flagged. He’s not happy about it.

The Journal of Biological Chemistry has retracted two papers by a Georgia State University researcher, as well as flagged eight more with expressions of concern, a move the scientist called “unfair and unjustified.”

Ming-Hui Zou, the common author on all ten papers — as well as on two more that have been corrected by the same journal — is, according to Georgia State,

an internationally recognized researcher in molecular and translational medicine and a Georgia Research Alliance Eminent Scholar in Molecular Medicine and associate vice president for research at Georgia State University…

Zou was at the University of Oklahoma when the papers in question were published. He moved to Georgia State in 2015.

Here’s the retraction notice for “Reactive nitrogen species is required for the activation of the AMP-activated protein kinase by statin in vivo,” published in 2008 Zou as the last author:

Forensics Friday: How was this image manipulated?

Ever wanted to hone your skills as a scientific sleuth? Now’s your chance.

Thanks to the American Society for Biochemistry and Molecular Biology (ASBMB), which is committed to educating authors on best practices in publishing, figure preparation, and reproducibility, we’re presenting the second in a series, Forensics Friday.

Take a look at the image below, and then take our poll. After that, click on the link below to find out the right answer.

Biochemist in Spain retracts eight papers at once

A high-profile researcher at the Universidad de Oviedo in Spain has retracted eight papers from the Journal of Biological Chemistry for figure issues.

All of the papers were co-authored by Carlos López-Otín, who studies a group of enzymes that break down proteins, cancer genomics and aging, and whose lab web site boasts that

His works have been collected in more than 400 articles in international journals and have been cited to date more than 44.000 times, with an aggregate Hirsch index of h=100.

A representative notice: Continue reading Biochemist in Spain retracts eight papers at once

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