Former Yale prof faked data, says Federal watchdog

Carlo Spirli

A liver researcher who worked at Yale University for 15 years faked data in multiple papers and grant applications, according to the U.S. Office of Research Integrity (ORI).

Carlo Spirli, who rose to the rank of associate professor before leaving Yale in 2020, “engaged in research misconduct by knowingly, intentionally, or recklessly falsifying and/or fabricating data” in four published papers, two presentations, and three NIH grant applications, the ORI said in announcing its findings today.

Spirli, according to the ORI:

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US federal research watchdog gets new permanent director

Sheila Garrity

The U.S. Office of Research Integrity, the agency that oversees research misconduct investigations for work funded by the National Institutes of Health (NIH), has a new permanent director after a year and a half without one. 

Sheila Garrity, currently associate vice president for research integrity and research integrity officer at George Washington University in Washington, D.C., will start as ORI’s next permanent director the week of March 26, according to an internal memo from Rachel Levine, the Biden Administration’s Assistant Secretary for Health. 

Garrity previously was director of the division of research integrity at Johns Hopkins University, where she worked for more than 20 years. She also was a founding member and the first president of the Association for Research Integrity Officers (ARIO). 

Levine’s memo described Garrity as “a leader in the fields of research integrity and the responsible conduct of research education,” and asked staff to “join me in welcoming Sheila to the OASH family and in thanking Wanda Jones for the incredible job she has done in running ORI while we conducted our candidate search.”

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Cancer researcher banned from federal funding for faking data in nearly 400 images in 16 grant applications

A former associate professor at Purdue University faked data in two published papers and hundreds of images in 16 grant applications, according to a U.S. government research watchdog. 

Alice C. Chang, whose publications and grants listed her name as Chun-Ju Chang, received nearly $700,000 in funding from the National Institutes of Health (NIH) through grant applications that the U.S. Office of Research Integrity (ORI) said contained fake data. She will be banned from receiving federal grants for a decade – a more severe sanction than ORI has typically imposed in recent years.

In its findings, ORI said Chang, who was an associate professor of basic medical sciences at Purdue’s College of Veterinary Medicine:

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Biotech exec stole an image and reused others while in academia, US federal watchdog says

Douglas Taylor

A pioneer in the field of exosome biology engaged in research misconduct by reusing images he had falsely relabeled in two published papers and several grant applications, according to a U.S. government research watchdog. 

The case goes back several years, as the scientist’s former institution seems to have been investigating his work for nearly a decade. 

Douglas Taylor, who in the 1970s discovered that tumor cells release exosomes, “used falsely labeled images to falsely report data in figures, and in one finding, intentionally, knowingly, or recklessly plagiarized, reused, and falsely labeled an image to falsely report data in a figure,” according to the published finding from the U.S. Office of Research Integrity (ORI). 

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Psychiatrist in Canada faked brain imaging data in grant application, U.S. federal watchdog says

Romina Mizrahi

A psychiatrist studying the development of psychosis faked data from studies of brain imaging in a grant application to the National Institutes of Health, a U.S, government watchdog has found. 

The federal Office of Research Integrity (ORI) announced sanctions against Romina Mizrahi, associate chair of research in McGill University’s department of psychiatry in Montreal, Canada, for “intentionally, knowingly, or recklessly falsifying data” in a grant application to the National Institute of Mental Health. 

Mizrahi submitted the grant application in question, R01 MH118495-01, “Imaging nociceptin receptors in clinical high risk and first episode psychosis,” in February 2018; it does not appear to have been funded. 

According to ORI, Mizrahi:

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Exclusive: UCLA found a longtime researcher faked data – but made a strange mistake in its report

UCLA

A few years ago, funding for the UCLA pathology lab where Janina Jiang had worked since 2010 was running out. 

The head of the lab was grateful when another scientist offered to chip in $50,000 to keep Jiang on for six more months. 

But some of the experiments Jiang – perhaps feeling that her job was on the line, a colleague speculated – ran for that scientist raised suspicions. Other experiments didn’t corroborate her results, and Jiang failed to provide all her raw data. 

Jiang’s benefactor asked another staff scientist to review and reanalyze her work. 

What he found spurred an institutional investigation, which in July 2021 found Jiang faked data representing flow cytometry experiments in several figures included in 11 grant proposals, resulting in 19 counts of research misconduct. 

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US federal research watchdog wants your input

A U.S. government watchdog for scientific misconduct has floated the possibility of revising some of its regulations, and it wants your thoughts on what should change. 

The Office of Research Integrity recently issued a Request for Information – essentially an email inbox open for suggestions – to help shape its potential revision of the 2005 Public Health Service Policies on Research Misconduct, 42 C.F.R. Part 93 in the federal code. 

These regulations define what “research misconduct” means for work funded by the U.S. Public Health Service – the oft-quoted “falsification, fabrication, and plagiarism” – and establish how the government and research institutions respond to these issues. 

The current regulations replaced rules issued in 1989, the same year the Office of Scientific Integrity in the National Institutes of Health and the Office of Scientific Integrity Review in the U.S. Department of Health and Human Services were created. These two offices were merged into the Office of Research Integrity in 1992. 

Here’s the meat of the request: 

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UCLA walks back claim that application for $50 million grant included fake data

UCLA

More than a month after a federal watchdog announced that a UCLA scientist had included fake data in a grant application worth more than $50 million, the university says the application didn’t have issues, after all.

In early August, the U.S. Office of Research Integrity (ORI) said that Janina Jiang faked data in eleven grant applications from UCLA. At the time, based on what was available in the ORI’s report, we noted:

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Former NCI postdoc faked data, says federal watchdog

A former postdoc at the National Cancer Institute faked 15 figures and a movie in grant applications, presentations, a paper, and an unpublished manuscript, according to a federal watchdog.

The finding from the U.S. Office of Research Integrity (ORI) comes more than a year after PLOS Biology retracted a 2016 paper and noted that the National Institutes of Health (NIH) had found that the postdoc, Ritankar Majumdar, committed misconduct and faked data in two figures. 

The same day, the journal republished a revised version without the faked data. The retracted paper has been cited 107 times, 13 of those after it was retracted, according to Clarivate’s Web of Science. The revised paper — which included Majumdar as a first author — has been cited eight times. 

The retraction notice stated that Majumdar agreed with the retraction but that he “disputes the NIH’s finding of misconduct.” 

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‘A significant departure’: Former Kentucky researcher faked 28 figures in grant applications and papers, say Feds

Stuart Jarrett

A former researcher at the University of Kentucky committed misconduct in both published papers and grant applications, according to a federal watchdog.

The finding from the Office of Research Integrity (ORI) comes two years after the University of Kentucky announced that it had concluded that the scientist, Stuart Jarrett, had committed misconduct on four papers and two federal grant applications – and demoted his supervisor.

Jarrett, a Wales native who left the school in September 2019, faked data in studies of melanoma and reported it in 28 figures in four papers, one funded NIH grant, and two unfunded NIH grants, according to ORI. “[T]hese acts constitute a significant departure from accepted practices of the relevant research community,” ORI said. 

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