expression of concern – Retraction Watch

Science places expressions of concern on two articles as Toronto’s Sinai Health investigates

Science has issued expressions of concern for two articles from the lab of Daniel Durocher, a professor of molecular genetics at the University of Toronto.

The notices, and two more editor’s notes on Nature articles, follow PubPeer comments on several of Durocher’s papers pointing out potentially duplicated images, as described by ForBetterScience. Durocher has responded to many of the comments promising to look into the issues.

Besides his academic positions at Toronto and the Lunenfeld-Tanenbaum Research Institute at Sinai Health, Durocher co-founded Repare Therapeutics, a biotech company with five ongoing clinical trials of potential treatments for cancer.

The two Science articles, “Mitosis inhibits DNA double-strand break repair to guard against telomere fusions” from 2014, and “Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase,” from 2007, together have been cited nearly 1,000 times, according to Clarivate’s Web of Science.

‘Mistakes were made’: Paper by department chair earns expression of concern as more questioned

A 14-year-old paper has earned an expression of concern after an anonymous whistleblower found evidence of image duplication in the work.

The authors have had images from several more papers flagged on PubPeer. The corresponding author, Kelly McMasters, is chair of the Hiram C. Polk, Jr., MD Department of Surgery at the University of Louisville School of Medicine in Kentucky.

The 2010 paper, “Adenovirus-mediated expression of truncated E2F-1 suppresses tumor growth in vitro and in vivo,” appeared in Cancer. It has been cited 12 times, according to Clarivate’s Web of Science.

Expression of concern coming for paper some used to link COVID-19 vaccines to deaths

The journal BMJ Public Health is placing an expression of concern on a paper it said “gave rise to widespread misreporting and misunderstanding,” namely, “claims that it implies a direct causal link between COVID-19 vaccination and mortality.”

The article, “Excess mortality across countries in the Western World since the COVID-19 pandemic: ‘Our World in Data’ estimates of January 2020 to December 2022,” appeared online June 3, and quickly attracted attention and criticism. The expression of concern is not yet live.

In their conclusions, the authors wrote:

Embattled researcher Didier Raoult earns more than 100 expressions of concern and another retraction

An Elsevier journal has issued just over 100 expressions of concern for papers published by a group of researchers led by the French microbiologist Didier Raoult, who also notched a new retraction – his tenth – in a separate publication.

As we and others have reported, Raoult’s work during the COVID-19 pandemic drew intense scrutiny from data sleuths, most notably Elisabeth Bik – whose critiques, which extended beyond his COVID studies, were met with vicious online trolling and a legal complaint filed by Raoult himself.

The allegations prompted an ethics investigation by the French National Agency for the Safety of Medicines and Health Products into Raoult’s research during his tenure at the IHU Méditerranée Infection, in Marseille, which he led between 2011 and his retirement as director in 2022. That inquiry found “serious shortcomings and non-compliances with the regulations for research involving the human person.”

The 101 expressions of concern come for papers Raoult and his colleagues published in New Microbes and New Infections. Here’s an example of one of the EoC’s, for “Genome sequence and description of Anaerosalibacter massiliensis sp. nov.,” which Raoult’s group published in March 2016:

Cancer paper earns expression of concern nearly two years after investigation report is revealed

A Springer Nature journal has issued an expression of concern for a 16-year-old paper by Carlo Croce, the cancer researcher – and noted art collector – at The Ohio State University three years after the publication had received a correction for problematic images and roughly 20 months after the news division at Nature reported on a pair of institutional investigations into problems with Croce’s work.

As we and others have reported, those investigations concluded Croce had not committed misconduct but had overlooked the misdeeds of others in his lab.

Here’s the notice for the paper, “MicroRNA signatures of TRAIL resistance in human non-small cell lung cancer,” which Oncogene published in 2008:

Science ‘Majorana’ particle paper earns another editor’s note as expert committee finds no misconduct

A paper that led to hopes that Microsoft might one day build a quantum computer has “shortcomings” that do not rise to the level of misconduct, according to an expert panel convened by the University of Copenhagen.

The paper, originally published in March 2020 in Science, earned an expression of concern in 2021 following critiques of the work from two researchers, Sergey Frolov and Vincent Mourik. This week, Science editor in chief Holden Thorp replaced the expression of concern with an editor’s note referring to a new report from a panel of experts at the University of Copenhagen, saying “we are alerting readers to this report while we await a formal decision on the matter from the Danish Committee on Research Misconduct.”

The panel’s report, dated Feb. 15, 2024, describes several of what it calls “shortcomings” but says “the excluded data did not undermine the paper’s main conclusions.” They also conclude the authors did not engage in “gross negligence” or scientific misconduct.

The last author of the Science paper, Charles Marcus, of the University of Washington, in Seattle, and the University of Copenhagen’s Niels Bohr Institute, told Retraction Watch he and his colleagues followed the recommendations by posting:

Science rescinds expression of concern issued last month

Science has rescinded an expression of concern it issued one month ago after the authors provided data that “addressed concerns about the integrity of the paper.”

The journal had published the expression of concern for the 2021 article “Light-induced mobile factors from shoots regulate rhizobium-triggered soybean root nodulation” after two separate readers contacted the editorial team about an issue in the paper, as we reported at the time. The expression of concern noted that “that data presented in Fig. 5 assessed GmNSP1 expression rather than GmNIN expression.”

The article has been cited 43 times, according to Clarivate’s Web of Science.

The journal is publishing the newly submitted data as a correction, as well as an editor’s note explaining the removal of the expression of concern. The new notice states:

Science paper marked with expression of concern after readers pointed out data issue

A paper published in Science two years ago has been flagged with an expression of concern while the editors give the authors a chance to correct a data issue identified by two different readers.

“Light-induced mobile factors from shoots regulate rhizobium-triggered soybean root nodulation,” was published in September 2021 and has been cited 43 times, according to Clarivate’s Web of Science.

The notice, published today, states:

PLOS flags nearly 50 papers by controversial French COVID researcher for ethics concerns

The publisher PLOS is marking nearly 50 articles by Didier Raoult, the French scientist who became controversial for promoting hydroxychloroquine for treating COVID-19, with expressions of concern while it investigates potential research ethics violations in the work.

PLOS has been looking into more than 100 articles by Raoult, but determined that the issues in 49 of the papers, including reuse of ethics approval reference numbers, warrant expressions of concern while the publisher continues its inquiry.

In August of 2021, scientific sleuth Elisabeth Bik wrote on her blog about a series of 17 articles from IHU-Méditerranée Infection that described different studies involving homeless people in Marseille over a decade, but all listed the same institutional ethics approval number. One of those papers, “Distinguishing Body Lice from Head Lice by Multiplex Real-Time PCR Analysis of the Phum_PHUM540560 Gene,” about which Bik also posted on PubPeer, was published in PLOS ONE in 2013, and is receiving an expression of concern today.

A paper used capital T’s instead of error bars. But wait, there’s more!

Mere days after tweets went viral pointing out that the purported error bars in one figure of a paper were really just the capital letter T, the publisher has marked it with an expression of concern. [12/22/22: The paper has now been retracted; see an update on this post.]

And that’s not all that’s strange about the paper.

The July 2022 article, “Monitoring of Sports Health Indicators Based on Wearable Nanobiosensors,” was published in a special issue of the journal Advances in Materials Science and Engineering, a Hindawi title.

The article purports to show that using nanoparticles can better measure the biochemical fitness levels of elderly people than other methods.

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