On Sept. 2, 2021, a professor at the University of Iowa, in Iowa City, emailed a biochemistry journal asking to correct a paper she had published the previous year. An experiment had “unintentionally” been omitted from a figure, Isabella Grumbach explained, and a comparison of experimental groups contained “a minor error in the degree of statistical significance.” A correction ensued.
But the problems with the article, “Inhibition of CaMKII in mitochondria preserves endothelial barrier function after irradiation,” appear to have been more deep-rooted than the email suggested. An anonymous commenter on PubPeer had first raised concerns about the article, which had appeared in Free Radical Biology and Medicine (FRBM), in July 2021, more than a year after it was published. The commenter claimed error bars between two figures were vastly different, even though they were meant to be related data points.
Continue reading How a sleuth’s email turned a correction into a retraction