Didier Raoult papers earn expressions of concern as criminal investigation gets underway

Didier Raoult

A leading microbiology society has issued expressions of concern for four six papers from a group in France led by the controversial scientist Didier Raoult, whose lab is under investigation by the  University of Aix Marseille for “serious malfunctions.” 

The move follows the release last month of a 157-page report by investigators related to France’s Health Ministry the university into Raoult’s research and news that a criminal investigation is underway

As we and others have reported, Raoult was among the most prominent floggers of the notion that hydroxychloroquine could treat COVID-19. But while his studies of the drug might have influenced certain American politicians, they and other research from his group haven’t withstood the scrutiny of his peers

He also has attempted to silence critics of his work, notably Elisabeth Bik, using legal threats and harassment

Continue reading Didier Raoult papers earn expressions of concern as criminal investigation gets underway

Chinese hospital sanctioned at least 35 scientists for research misconduct

Retractions are rolling along for numerous scientists affiliated with the Jining First People’s Hospital in Shandong, China, who were sanctioned in December for research misconduct such as tampering with data and fabricating research.  

For example, one article, “Lycium barbarum polysaccharides alleviates oxidative damage induced by H2O2 through down-regulating microRNA-194 in PC-12 and SH-SY5Y cells,” which appeared in Cellular Physiology and Biochemistry in 2018, was retracted on August 31. 

The retraction notice stated:

Continue reading Chinese hospital sanctioned at least 35 scientists for research misconduct

When an independent replication isn’t really independent

Matt Warman

My laboratory at Boston Children’s Hospital and Harvard Medical School studies genetic diseases that affect the skeletal system.  We became interested in the protein osteocalcin after Gerard Karsenty at Columbia University reported in several papers using knockout mice – mice lacking the genes which produce osteocalcin – that osteocalcin is a bone-derived hormone that affects glucose metabolism, insulin production, male fertility, muscle mass, and cognition.  If osteocalcin functions similarly in humans, then osteocalcin becomes an exciting and clinically important protein. 

To independently confirm these findings, we created our own osteocalcin knockout mouse strain. We examined glucose metabolism and male fertility in our mice and found none of the effects reported by Karsenty and colleagues; we reported our findings in May 2020.  A group in Japan created a third osteocalcin knockout mouse strain which also failed to confirm Karsenty and colleagues’ findings.  

In earlier years my laboratory also could not independently confirm other results reported by the Karsenty group: a paper I co-authored in 2011 found no evidence of the Wnt co-receptor LRP5 affecting blood serotonin levels, contrary to what Karsenty’s lab published.

Continue reading When an independent replication isn’t really independent

Doctor faces apparent retaliation after alleging data manipulation in published trial

Fouad Fayad

A rheumatologist was suspended from a professional society and his license to practice medicine was threatened after he raised concerns about data manipulation in a published study for which he recruited patients, according to documents seen by Retraction Watch. 

The study, “Added Value of Anti-CD74 Autoantibodies in Axial SpondyloArthritis in a Population With Low HLA-B27 Prevalence,” was published in Frontiers in Immunology in 2019 and has been cited 13 times, according to Clarivate’s Web of Science. In its acknowledgements, it listed Fouad Fayad, a rheumatologist at the University of Saint Joseph and Hotel-Dieu de France University Medical Center in Beirut, as one of the researchers who recruited patients for the trial. 

Fayad alleged that the researchers tested patient samples multiple times and used a mix of old and new values in their analysis. After he reported his concerns to the journal and then the university, which both concluded that they could not confirm or refute his allegations, he has faced apparent retaliation, including the suspension of his membership in the Lebanese Society of Rheumatology. 

In comments to Retraction Watch, the corresponding author for the study noted that the two investigations did not find data manipulation, and said the issue was “based on a background of personal and professional conflicts.” 

Continue reading Doctor faces apparent retaliation after alleging data manipulation in published trial

Papers in Croce case with “blatantly obvious” problems still aren’t retracted after misconduct investigation: sleuth

Carlo Croce

This week, Nature reported on two institutional reports that found scientists in Carlo Croce’s cancer research lab at The Ohio State University had committed research misconduct including plagiarism and data falsification. 

Another institutional investigation directed at Croce did not find he committed research misconduct but did identify problems with how he managed his lab, according to Nature

It’s the latest chapter in a years-long saga of mounting numbers of corrections and retractions for Croce, a 2017 article in the New York Times that brought him to widespread attention, a scientist sleuth trying to clean up the literature, and lots and lots of lawyers, some of whom may have a claim  on Croce’s house after he didn’t pay his legal bills.

Continue reading Papers in Croce case with “blatantly obvious” problems still aren’t retracted after misconduct investigation: sleuth

Lawsuit prompts retraction of book chapter on outdated birth surgery

Oonagh Walsh

Springer Nature has retracted a 2020 chapter in a digital book – along with a related introduction – after a judge in Ireland ruled that the paper defamed another researcher and two attorneys. 

“Truth or Dare; Women, Politics, and the Symphysiotomy Scandal”, was written by Oonagh Walsh, a professor of gender studies at Glasgow Caledonian University. The text appeared as Chapter 11 in the e-book GeoHumanities and Health, Global Perspectives on Health Geography.

The scandal, according to The Guardian, involved the controversial use of a surgery in which physicians: 

Continue reading Lawsuit prompts retraction of book chapter on outdated birth surgery

Author objects to “irrelevant reviewers” as journal retracts four papers

Muhammad Aslam

Springer Nature’s Scientific Reports has retracted four papers by a researcher in Saudi Arabia who claims “irrelevant reviewers” just couldn’t understand “a new area of statistics.” 

Here’s the notice for one of the articles, “Neutrosophic statistical test for counts in climatology,” which appeared in September 2021 and has been cited once, according to Clarivate’s Web of Science: 

Continue reading Author objects to “irrelevant reviewers” as journal retracts four papers

Japanese university recommends five retractions after investigating botany researcher

Kyoto University is recommending retraction for five papers by a former botany researcher there after an institutional inquiry turned up evidence of fraud. 

The investigation of Lianwei Peng, who left the school in May 2011, found 11 images had been manipulated in the papers, according to a press release. The corresponding author on all five papers, Toshiharu Shikanai, may face disciplinary action, the university’s statement said. 

Shikanai’s faculty page at Kyoto University, shown here in an archived snapshot from November 2020, now bears a message that “the requested page cannot be found.”

Continue reading Japanese university recommends five retractions after investigating botany researcher

February: ‘we don’t agree there is an issue here.’ June: Retracted.

Rady El-Araby

A Springer Nature journal has retracted a paper on hepatitis C infection it had previously corrected for problematic data – but in between the editors declared the case closed.

The paper, “The interaction between microRNA-152 and DNA methyltransferase-1 as an epigenetic prognostic biomarker in HCV-induced liver cirrhosis and HCC patients,” was published in July 2019 in Cancer Gene Therapy. The authors were affiliated with Al-Azhar University, in Cairo, and the Ministry of Scientific Research, in Gizah, Egypt.  

Some two years later, Alexander Magazinov – a data sleuth about whom we’ve written beforeposted concerns on PubPeer about the article and three other papers by members of the group.  

Continue reading February: ‘we don’t agree there is an issue here.’ June: Retracted.

UPenn prof with four retractions “may no longer be affiliated” with school

William Armstead

A pharmacology researcher with four retractions appears to have left the University of Pennsylvania, where he had worked for at least 30 years and won more than $7 million in NIH grants.

The school’s faculty page for William Armstead, who held ​​a research professorship in Anesthesiology and Critical Care, now bears only the statement that “Dr. Armstead may no longer be affiliated with the Perelman School of Medicine.” Penn Medicine has not responded to our request for comment.  

In May, we reported that Armstead was up to four retractions after the Journal of Neurotrauma had retracted three articles at the researcher’s request. 

Continue reading UPenn prof with four retractions “may no longer be affiliated” with school