Archive for the ‘oncology retractions’ Category
Should scientific misconduct be handled by the police? It’s fraud week at Nature and Nature Medicine
Those are three highlights from a number of pieces that have appeared in Nature and Nature Medicine in the past few weeks. Not surprisingly, there are common threads, so join us as we follow the bouncing ball. Read the rest of this entry »
The retraction notice for the paper, “Drugs in development for treatment of patients with cancer-related anorexia and cachexia syndrome,” fairly bristles with indignation: Read the rest of this entry »
Two cancer researchers who hold a patent on a particular pathway that might be a target for new drugs — and one of whom leads a company that is studying those potential drugs — have retracted two related papers in the Journal of Biological Chemistry (JBC).
The notices for “Kinase suppressor of Ras signals through Thr269 of c-Raf-1“ and “The kinase activity of kinase suppressor of Ras1 (KSR1) is independent of bound MEK,” which share H. Rosie Xing and Memorial Sloan-Kettering’s Richard Kolesnick as authors, say the same thing: Read the rest of this entry »
The journal Case Reports in Medicine has retracted a 2012 article by a group of Turkish authors who made up things in the piece.
The paper, “Brain Metastasis as an Initial Manifestation of Ovarian Carcinoma: A Case Report,” came from ob-gyns at Hacettepe University in Ankara, and purported to relate the case of
A 30-year-old gravida 2, para 2 woman admitted to our hospital with complaints of headache, nausea, vomiting, and right-sided blurred vision. She did not report any previous medical history or malignancy. Her neurologic examination revealed a right optic disc edema suggesting a posterior orbital mass. Her cranial computerized tomography (CT) scan showed multiple lesions that are a 6 mm mass on the right parietal lobe, a 16 mm mass on the left occipital, and another 7 mm mass on the left temporal lobe (Figures 1 and 2). All the lesions were hyperintense and surrounded by edema which suggests a metastatic cancer. Her cranial magnetic resonance imaging (MRI) also confirmed similar findings suggestive of a metastatic cancer to the brain. Read the rest of this entry »
The Journal of Biological Chemistry has a fairly gory correction — we’d call it a mega-correction — for a 2010 paper by Levon Khachigian, an Australian researcher whose studies of a new drug for skin cancer recently were halted over concerns about possible misconduct, including image manipulation. As we reported earlier this year, Khachigian has already lost four papers, including one in the JBC — which the journal simply noted had “been withdrawn by the authors.”
The new correction involves the article “c-Jun regulates shear- and injury-inducible Egr-1 expression, vein graft stenosis after autologous end-to-side transplantation in rabbits, and intimal hyperplasia in human saphenous veins,” which Khachigian wrote with Jun Ni and Alla Waldman. The paper has been cited nine times, according to Thomson Scientific’s Web of Knowledge. Here’s the notice: Read the rest of this entry »
A leading Neapolitan cancer researcher is under criminal investigation for fraud, the Italian press is reporting.
Although we have only rough translations of the story, it seems the researcher, Alfredo Fusco, of the National Council of Research’s Institute of Experimental Endocrinology and Oncology, has been accused of manipulating images in published studies and to strengthen the case for grants from the Italian Association for Cancer Research (AIRC).
The case covers eight papers published between 2001 and 2012, according to the media reports. We don’t know the specifics of the eight articles, nor why none appears yet to have been retracted. In our experience, the criminal inquiries usually follow the expose of scientific misconduct, not the other way around.
Fusco’s work is highly cited, with some 50 papers cited at least 100 times, according to Thomson Scientific’s Web of Knowledge.
According to the institute’s website: Read the rest of this entry »
The retraction notices for “PM02734 (Elisidepsin) Induces Caspase-Independent Cell Death Associated with Features of Autophagy, Inhibition of the Akt/mTOR Signaling Pathway, and Activation of Death-Associated Protein Kinase” and “The Phosphatase Inhibitor Menadione (Vitamin K3) Protects Cells from EGFR Inhibition by Erlotinib and Cetuximab” say the same thing: Read the rest of this entry »
The fifth of six expected retractions for copyright infringement has arrived for a group of sex researchers led by Willibrord Weijmar Schultz, this one in the International Journal of Gynecological Cancer of a 1992 article.
As we reported earlier this year, Schultz (whose 1999 paper on sex in an MRI won an Ig Nobel prize) and his colleague, Mels F. Van Driel, were found not to have committed plagiarism by investigators at the University of Groningen. Instead, they were found guilty of “unintended and unknowing breach of copyright.”
But they were asked to apologize formally to a litany of people — from the editors involved to the sponsors of the research — for what the institution described as “unintended and unknowing breach of copyright” of the work of one Diana Jeffrey, whose 1985 dissertation evidently was very much worth reading.
Here’s the latest retraction notice: Read the rest of this entry »