What happened appears to be a case of “he said, she said:” Littman asked to retract the paper after his lab couldn’t reproduce it, and Huang insists the data remain correct, saying the process had been “unfair and done without due process:”
What Caught Our Attention: Usually, when journals publish corrections to articles, they also correct the original article, except when the original is unavailable online. When Nature noticed that some figure panels in a 20-year-old paper were duplicated, it flagged the issue for readers — but didn’t correct the online version of the original paper. According to the notice, the duplications don’t disturb the conclusion illustrated by the figure, the original data couldn’t be found, and the last two authors had retired. We contacted a spokesperson at Nature, who told us “the information at the start of the paper clearly links to the corrigendum.” Continue reading Caught Our Notice: Yes, a 20-year-old article is wrong — but it won’t be corrected online
How much role did a potentially problematic paper play in the demise of a once-promising compound?
Researchers are questioning the validity of a high-profile article, published by Nature in 2006. Although the letter is 12 years old, the concerns have current implications: It was among the early evidence used to develop a cancer compound that recently failed a number of clinical trials.
It’s unclear whether the problems with the paper — if validated — could have contributed to the compound’s demise. But an outside expert has some thoughts — and so do image experts and multiple external reports, including one released this month, which agree the concerns about the figures have merit. (The first author’s ex-husband isn’t too happy with the article, either.)
Nature has added an “editor’s note” to a high-profile August paper alerting readers to the fact that the article has been subject to criticism.
Journals often flag papers that are being debated — what’s unusual here is that the journal doesn’t label the notice as an official “Expression of Concern,” which are indexed by PubMed. Yet the Nature notice reads just like an expression of concern.
Statisticians are mounting a challenge to a much-publicized study suggesting that human lifespan has a limit of approximately 115 years — 125, tops.
Published last October in Nature, the study from scientists at Albert Einstein College of Medicine in New York was the eleventh most talked-about piece of research in 2016, according to Altmetric. The paper is not yet indexed in Clarivate Analytics’ Web of Science.
But now, multiple research teams have described what they see as flaws in either the statistical methods or underlying reasoning of the study. Today, Nature published five peer-reviewed rebuttals, in response to the study. Another scientist described his concerns about the paper in April in F1000 Research.
The five papers in Nature are published as Brief Communications Arising, the journal’s way of flagging an important debate over a paper. The short papers provide new data to challenge a central part of a paper’s conclusions. The study’s authors, however, have responded to all five, defending their methods, especially their controversial decision to rely in part upon a visual inspection of mortality data in concluding there is a limit to human lifespan. Senior author Jan Vijg, a geneticist, told Retraction Watch:
Recently, a biostatistician sent an open letter to editors of 10 major science journals, urging them to pay more attention to common statistical problems with papers. Specifically, Romain-Daniel Gosselin, Founder and CEO of Biotelligences, which trains researchers in biostatistics, counted how many of 10 recent papers in each of the 10 journals contained two common problems: omitting the sample size used in experiments, as well as the tests used as part of the statistical analyses. (Short answer: Too many.) Below, we have reproduced his letter.