Archive for the ‘jbc retractions’ Category
Two cancer researchers who hold a patent on a particular pathway that might be a target for new drugs — and one of whom leads a company that is studying those potential drugs — have retracted two related papers in the Journal of Biological Chemistry (JBC).
The notices for “Kinase suppressor of Ras signals through Thr269 of c-Raf-1“ and “The kinase activity of kinase suppressor of Ras1 (KSR1) is independent of bound MEK,” which share H. Rosie Xing and Memorial Sloan-Kettering’s Richard Kolesnick as authors, say the same thing: Read the rest of this entry »
A group of authors from Emory University, has lost another paper for image manipulation, bringing their total to at least four. What makes this particularly interesting is that the main actor in the figure fakery, Lian Zuo, does not appear to have been involved this time.
Zuo, you may recall, was cited in multiple retraction notices back in 2011 after Emory investigators concluded that he appeared to have been fabricating figures. But, one of the notices, from Circulation Research, raised the possibility that someone else was implicated, too: Read the rest of this entry »
The Journal of Biological Chemistry has a fairly gory correction — we’d call it a mega-correction — for a 2010 paper by Levon Khachigian, an Australian researcher whose studies of a new drug for skin cancer recently were halted over concerns about possible misconduct, including image manipulation. As we reported earlier this year, Khachigian has already lost four papers, including one in the JBC — which the journal simply noted had “been withdrawn by the authors.”
The new correction involves the article “c-Jun regulates shear- and injury-inducible Egr-1 expression, vein graft stenosis after autologous end-to-side transplantation in rabbits, and intimal hyperplasia in human saphenous veins,” which Khachigian wrote with Jun Ni and Alla Waldman. The paper has been cited nine times, according to Thomson Scientific’s Web of Knowledge. Here’s the notice: Read the rest of this entry »
The study, “Sirtuin 2 (SIRT2) enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via deacetylating forkhead box O3a (Foxo3a) and activating Bim protein,” by Gizem Donmez and colleagues, had already been subject to an extensive correction in May: Read the rest of this entry »
An Australian university has put a hold on trials of an experimental drug for skin cancer whose main developer has been dogged by charges of research misconduct for several years.
The Australian Broadcasting Corporation is reporting that the University of New South Wales has suspended trials of the drug, DZ13, while it investigates the work of Levon Khachigian, who is leading the studies.
According to the news organization, Khachigian and his group were cleared by the school in two prior inquiries. However, additional accusations of misconduct — specifically involving image manipulation and misuse — prompted a third investigation.
We’ve found four retractions of Khachigian’s studies, from the Journal of Biological Chemistry and Biochemical and Biophysical Research Communications, between 2009 and 2010 (before the launch of Retraction Watch).
They are: Read the rest of this entry »
We have knocked the Journal of Biological Chemistry in the past for what we believed to be needless — and unhelpful — obfuscation. And more recently, we have praised the journal for taking what we believe to be positive steps in the direction of greater transparency.
Here, again, we come not to bury JBC but to praise it.
The journal has issued a retraction for a 2011 article by a group of researchers in London, England, led by Stephen Perkins. The paper, “The solution structure of heparan sulfate differs from that of heparin,” purported to show that:
Read the rest of this entry »
The paper, “Static High-Gradient Magnetic Fields Activate Transient Receptor Potential Vanilloid 4 (TRPV4) Ion Channels Enabling Remote Control of Cell Function,” whose corresponding author is Thomas Simmet of Ulm University, appeared online on June 11. Since June 24, the PDF of the paper has been stamped: Read the rest of this entry »
Former National University of Singapore and University of Liverpool scientist Alirio Melendez has two more of the 20-something retractions suggested by the investigations into his work. Both appear in the Journal of Biological Chemistry.
Last November we wrote about the case of Alejandra Bravo and Mario Soberón, a wife-husband team of microbiologists studying genetically modified crops, who had been disciplined by the National Autonomous University of Mexico for having manipulated images in 11 papers.
The tinkering did not rise to the level of fraud, according to the university — which perhaps helps explain why it didn’t lead to requests for retractions, according to Soberón. Instead, he said at the time, at least seven journals would be issuing corrections. We now have what appears to be the first of these, in the Journal of Biological Chemistry. Read the rest of this entry »