Archive for the ‘jbc retractions’ Category
When journals learn papers are problematic, how long does it take them to act?
We recently had a chance to find out as part of our continuing coverage of the case of Anil Jaiswal at the University of Maryland, who’s retracted 15 papers (including two new ones we recently identified), and has transitioned out of cancer research. Here’s what happened.
As part of a public records request related to the investigation, we received letters that the University of Maryland sent to 11 journals regarding 26 “compromised” papers co-authored by Jaiswal, four of which had been retracted by the time of the letter. The letters were dated between August and September 2016 (and one in February) — although, in some cases, the journals told us they received the letter later. Since that date, three journals have retracted nine papers and corrected another, waiting between four and six months to take action. One journal published an editorial note of concern within approximately two months after the university letter.
And six journals have not taken any public action.
Late last year, Carl Ronald Kahn—also chief academic officer at Joslin Diabetes Center—retracted two papers for similar reasons. In November, Kahn pulled a 2005 paper from The Journal of Clinical Investigation (JCI) and a month later, he retracted a 2003 paper from The Journal of Biological Chemistry (JBC), both times citing duplications that the authors said were introduced while assembling the figures.
Last month, Kahn retracted his third paper, also published in JBC in 2003, because the authors omitted data when constructing the images. Still, the authors remain confident in their findings, given that data from other labs “have confirmed and extended the conclusions of the manuscript.”
A biology society is hiring three editors to screen images in submissions to its journal, Journal of Biological Chemistry — which we think is a great idea.
We don’t typically mention job ads on our site, except when they become relevant to cleaning up the literature — and with the latest job ad, the JBC joins the ranks of other journals that have taken a proactive stance against image problems, including manipulation. The publisher, American Society for Biochemistry and Molecular Biology (ASBMB), plans to hire three “Technical Image Editors,” which will screen the images contained within the thousands of papers the journal publishes each year, many of which contain multiple panels and supplemental data.
Kaoru Sakabe, Data Integrity Manager at ASBMB, told us:
This weekend, Carlo Croce had some reprieve from the misconduct accusations that have followed him for years (recently described in a lengthy article in the New York Times) and that have prompted his university to re-open an investigation. On Sunday, he received a prestigious award from the American Association for Cancer Research, honoring his work.
But the moment may have been short-lived. Today, Croce received two expressions of concern (EOCs) from PNAS for two well-cited papers published over a decade ago, on which Croce — chair of the Department of Cancer Biology and Genetics at The Ohio State University (OSU) — is last author. The two EOCs cite concerns over duplicated bands. What’s more, another journal recently decided to retract one of his papers, citing figures that didn’t represent the results of the experiments.
PNAS chose to issue EOCs, rather than retractions or corrections, because the authors didn’t agree that the bands were duplicated, according to executive editor Diane Sullenberger. She explained how the journal learned of the issues with the two papers: Read the rest of this entry »
A scientist who sued his employer for millions of dollars has earned two more retractions, for papers that had already been flagged by the journal.
Kumar sued his employer, George Washington University, for $8 million, alleging emotional distress when they put him on leave from his position as department chair following a finding of misconduct. That suit was settled last year, for undisclosed terms.
The two newest retractions in the Journal of Biological Chemistry — which tagged the papers with Expressions of Concern last year — both state that, according to Kumar, the problematic figures were assembled by “specific co-authors” — unnamed — in his lab. Here’s the first notice:
A journal has retracted six papers by a cancer researcher at the University of Maryland in Baltimore, bringing his total to 10.
The retractions cite an investigation by the university, and detail problems ranging from duplicated images, to tweaking an image to conceal particular bands, to including unreliable data.
Three of the papers had already been flagged by the journal with expressions of concern. The last author on all the papers is Anil Jaiswal, a professor in the pharmacology department. He has issued four previous retractions.
Bruce Jarrell, the Chief Academic and Research Officer and Senior Vice President at the University of Maryland, told us at least two more retractions are forthcoming:
A researcher who claimed image problems in a retracted paper were the result of a software glitch, and not intentional, has lost three more papers — all for image manipulation.
In two notices, the Journal of Biological Chemistry specifies that duplicated images were used to represent different experimental conditions; one notice simply says the paper was affected by image manipulation.
All of the notices specify the papers are being retracted by the publisher, the American Society for Biochemistry and Molecular Biology — which this month published a set of recommendations for preparing a paper, including how to avoid excessive manipulation.
Here’s the first notice:
The former president of the Joslin Diabetes Center has withdrawn a second article within a month of his first, and issued extensive corrections to another paper in the same journal, all due to figure errors.
In November, we reported that Carl Ronald Kahn — also affiliated with Harvard Medical School — had pulled a highly cited 2005 paper from The Journal of Clinical Investigation because of image duplication issues, which Kahn told us were introduced during figure assembly. This December, Kahn retracted a 2003 paper published in The Journal of Biological Chemistry (JBC)—again due to duplication issues that the authors believe “were inadvertently introduced during figure assembly.”
Here’s the retraction notice for “Bi-directional regulation of brown fat adipogenesis by the insulin receptor,” cited 46 times, according to Clarivate Analytics’ Web of Science, formerly part of Thomson Reuters:
Four of the newly corrected papers have a common last and corresponding author: Luke O’Neill of Trinity College Dublin in the Republic of Ireland. O’Neill is also a co-author of the remaining paper that was fixed. O’Neill told us the mistakes were a “bit sloppy,” noting that he takes responsibility for the errors in the four papers on which he is last author.
O’Neill forwarded Retraction Watch a comment he received from Kaoru Sakabe — data integrity manager at the American Society for Biochemistry and Molecular Biology (which publishes The Journal of Biological Chemistry (JBC)) — that reads: Read the rest of this entry »
Following a journal probe and questions on PubPeer about their work, authors in Spain have issued four corrections, citing missing raw data for experiments conducted more than 10 years ago.
All papers include the same last two authors, Mireia Duñach at the Autonomous University of Barcelona, and Antonio García de Herreros at the Institut Hospital del Mar d’Investigacions Mèdiques.
Three of the corrections were issued by the Journal of Biological Chemistry, from which the authors retracted three papers earlier this year after a journal investigation concluded they contain reused images, designed to represent different experiments.
Duñach told us the latest corrections are the result of her own initiation: