ICYMI: Second paper by Nobel laureate Thomas Südhof retracted

Thomas Südhof

A 2017 paper coauthored by Nobel laureate Thomas Südhof has been retracted. 

The article, “Conditional Deletion of All Neurexins Defines Diversity of Essential Synaptic Organizer Functions for Neurexins,” was published in Neuron in May 2017 and has been cited 145 times, according to Clarivate’s Web of Science. 

The retraction notice, issued February 11, states:

We, the authors of this publication, have decided to retract the paper because we found that the images in Figure 1D and Figure S4B contain aberrations that cannot be explained, and the original data for these figures are missing. Raw data for the other components of the paper are available, and their reanalysis confirmed the conclusions of the paper. We would like to thank M. Schrag for bringing these image aberrations to our attention.

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ICYMI: Science editor encourages addressing integrity questions publicly

Holden Thorp

When scientists face critique of their published work, they should be proactive in responding to the issues and to questions about it from the public and the media, says Science editor-in-chief Holden Thorp in an editorial in the Feb. 14 Science.

“In an age of growing, intense attacks on science, silence can be detrimental to both public trust and the careers of scientists who are under scrutiny,” writes Thorp and coauthor Meagan Phelan, communications director for Science. “For better or worse, journalists, social media professionals, and the public may take a response of ‘no comment’ as a concession that the critics are correct, so forthright communication about research questions is more urgent than ever.”

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ICYMI: Science is considering retracting ‘arsenic life’ paper

Felisa Wolfe-Simon at Mono Lake in 2010 (photo by Henry Bortman)

Science is finally considering retracting a 2010 paper claiming the discovery of a bacterium that could substitute arsenic for phosphorus in its chemical makeup. “We feel the best thing to do would be to retract the paper,” the journal’s editor-in-chief Holden Thorp told the New York Times in an article published Tuesday. 

The article follows up with Felisa Wolfe-Simon, the lead author of the work who withdrew from science and public life after the intense spotlight from the work’s initial splash led to damaging criticism. She has recently gone back to the lab and in 2024 received a NASA exobiology grant.  

Retraction Watch readers may recall that Science published numerous technical comments and two studies refuting the original work. In 2012, David Sanders — who would later become well-known as a sleuth — said in our pages that the “only responsible action on the part of Science would be to retract the original article.”  He called again for the retraction in 2021.

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