Publisher retracting more than 30 articles from paper mills

The publisher SAGE is in the process of retracting more than 30 papers across three of its journals after determining that they were churned out by paper mills — prompting the company to take a closer look at its policies and procedures. 

The suspect papers were initially flagged by Elisabeth Bik and others as part of a group of some 400 articles that showed signs of having been milled. As we reported in March, a dozen of the articles were hit with expressions of concern — prompting some head-scratching from Bik, in particular, about why they weren’t being retracted outright. 

A spokesperson for SAGE told us: 

SAGE was made aware of claims of 13 potentially fraudulent papers in September 2020 via a public forum, and immediately launched an internal investigation. This investigation revealed suspected data manipulation of the same type in a further 18 papers across three journals. All 31 papers have been or are due to be retracted.

The papers were retracted due to suspected data manipulation and we found clear suggestions that these papers had been generated by what have been widely reported as “paper mills” and are as such compromised. The authors were asked to comment but the responses were unsatisfactory.

SAGE said its investigation:

revealed papers sharing striking similarities in methodology, images, and text. Ultimately, we found evidence of image manipulation and duplication in cell images and western blots. 

Through the course of this investigation, we have deepened our understanding of the characteristics to look out for that are common across paper mill submissions and are implementing additional checks to determine the legitimacy of data prior to acceptance. Additionally, since the publication of these articles, we have implemented internal procedures to guard against potential fraudulent submissions in the future as well as the risk of compromised peer review, including additional checks to validate the identity of authors and the relationships authors may have with reviewers (note that author-nominated reviewer fraud was not implicated in these cases).

We have since implemented more rigorous peer review processes that include critical evaluation of raw data and developed resources to aid in identifying characteristics of paper mill papers as highlighted in the public literature.

According to the retraction notice for one of the affected articles, “miR-451a Inhibits the Growth and Invasion of Osteosarcoma via Targeting TRIM66,” published in Technology in Cancer Research & Treatment, SAGE’s peer review process was breached: 

Significant similarities between this paper and a number of other papers have been identified, as well as indication of image and data manipulation suggestive of the use of a “paper mill”. These papers share common structures and wording yet do not share any common authors.

In addition, the Technology in Cancer Research & Treatment Editorial Office became aware that the peer review process for this article had been compromised, and we have reason to believe this was due to author misconduct.

The authors did not provide a sufficient response or evidence to refute these claims. As a result, the scientific accuracy of this paper is not reliable.

Adhering to the international guidelines established by the Committee on Publication Ethics, the Journal has determined these are grounds for retraction.

The three journals are Technology in Cancer Research & Treatment (which is pulling 12 papers), the International Journal of Immunopathology and Pharmacology (16) and the Journal of International Medical Research (3). Many of the affected papers have yet to receive notices. 

Here are the papers, along with the journals where they appeared:

Tanshinone inhibits neuronal cell apoptosis and inflammatory response in cerebral infarction rat model International Journal of Immunopathology and Pharmacology 
MicroRNA-132 protects hippocampal neurons against oxygen-glucose deprivation induced apoptosis International Journal of Immunopathology and Pharmacology  
Role of flunarizine hydrochloride in secondary brain injury following intracerebral hemorrhage in rats International Journal of Immunopathology and Pharmacology  
Total glucosides of paeony suppresses experimental autoimmune uveitis in association with inhibition of Th1 and Th2 cell function in mice International Journal of Immunopathology and Pharmacology  
Astragalus polysaccharide alleviates LPS-induced inflammation injury by regulating miR-127 in H9c2 cardiomyoblasts International Journal of Immunopathology and Pharmacology  
MicroRNA-145 attenuates IL-6-induced enhancements of sensitivity to UVB irradiation by suppressing MyD88 in HaCaT cells International Journal of Immunopathology and Pharmacology  
Possible treatment for cutaneous lichen planus: An in vitro anti-inflammatory role of angelica polysaccharide in human keratinocytes HaCaT  International Journal of Immunopathology and Pharmacology  
Tripterine up-regulates miR-223 to alleviate lipopolysaccharides-induced damage in murine chondrogenic ATDC5 cells  International Journal of Immunopathology and Pharmacology  
Triptolide inhibits benign prostatic epithelium viability, migration and induces apoptosis via up-regulation of microRNA-218 International Journal of Immunopathology and Pharmacology  
Kaempferol inhibits proliferation, migration and invasion of liver cancer HepG2 cells by down-regulation of microRNA-21 International Journal of Immunopathology and Pharmacology  
Notoginsenoside R1 protects human Keratinocytes HaCaT from LPS-induced inflammatory injury by downregulation of Myd88 International Journal of Immunopathology and Pharmacology  
Protective effects of Ginsenoside Rb1 on H2O2-induced oxidative injury in human endothelial cell line (EA.hy926) via miR-210 International Journal of Immunopathology and Pharmacology  
Skullcapflavone I protects cardiomyocytes from hypoxia-caused injury through up-regulation of lincRNA-ROR International Journal of Immunopathology and Pharmacology  
Green tea polyphenols protects PC12 cells against H2O2-induced damages by up-regulating lncRNA MALAT1 International Journal of Immunopathology and Pharmacology  
Typhae pollen polysaccharides protects hypoxia-induced PC12 cells injury via regulation of miR-34a/SIRT1 International Journal of Immunopathology and Pharmacology  
KCNQ1OT1 accelerates gastric cancer progression via miR-4319/DRAM2 axis International Journal of Immunopathology and Pharmacology  
miR-384 targets MTDH to suppress gastric cancer cell growth, migration and invasion  Journal of International Medical Research  
miR-152 inhibits the proliferation and invasion of chordoma cells by targeting HOXC8  Journal of International Medical Research  
miR-4324 functions as tumor suppressor in colorectal cancer by targeting HOXB2  Journal of International Medical Research  
Identification miR-758-3p as potential modulator of CBX5 expression in gastric cancer Technology in Cancer Research & Treatment   
microRNA-374a governs aggressive cell behaviors of glioma by targeting prokineticin 2 Technology in Cancer Research & Treatment  
miR-145-5p acts as a novel tumor suppressor in hepatocellular carcinoma through targeting RAB18 Technology in Cancer Research & Treatment  
miR-153-3p suppresses inhibitor of growth protein 2 expression to function as tumor suppressor in acute lymphoblastic leukemia Technology in Cancer Research & Treatment  
miR-299-3p/FOXP4 axis regulates the proliferation and migration of oral squamous cell carcinoma Technology in Cancer Research & Treatment  
Influence of miR-376c-3p/SYF2 axis on the progression of gastric cancer Technology in Cancer Research & Treatment  
miR-27a-3p functions as a tumor suppressor and regulates non-small cell lung cancer cell proliferation via targeting HOXB8 Technology in Cancer Research & Treatment  
miR-27b targets HOXB8 to inhibit malignant behaviors of osteosarcoma Technology in Cancer Research & Treatment  
miR-744-5p inhibits non-small cell lung cancer proliferation and invasion by directly targeting PAX2 Technology in Cancer Research & Treatment  
MicroRNA-663a regulates melanoma progression by inhibiting FHL3 Technology in Cancer Research & Treatment  
Long non-coding RNA H19 inhibits cell viability, migration and invasion via downregulation of IRS-1 in thyroid cancer cells Technology in Cancer Research & Treatment  
miR-451a inhibits the growth and invasion of osteosarcoma via targeting TRIM66 Technology in Cancer Research & Treatment  

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One thought on “Publisher retracting more than 30 articles from paper mills”

  1. Author-nominated peer review fraud not implicated, yet “…. the peer review process for this article had been compromised, and we have reason to believe this was due to author misconduct.”
    So how else do authors game peer review process?

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