Archive for the ‘ori investigations’ Category
That’s an important question, with an answer that may help determine how much attention some people pay to research misconduct. But it’s one that hasn’t been rigorously addressed.
Seeking some clarity, Andrew Stern, Arturo Casadevall, Grant Steen, and Ferric Fang looked at cases in which the Office of Research Integrity had determined there was misconduct in particular papers. In their study, published today in eLife: Read the rest of this entry »
A former postdoc at MD Anderson Cancer Center faked the results of a mouse study of a Novartis compound designed to fight brain tumors, according to the Office of Research Integrity (ORI).
Jun Fu “admitted to knowingly and intentionally falsifying Figure 8a” in “Novel HSP90 Inhibitor NVP-HSP990 Targets Cell-Cycle Regulators to Ablate Olig2-Positive Glioma Tumor–Initiating Cells,” a paper published in Cancer Research on May 15, 2013:
The Office of Research Integrity has sanctioned a former researcher in the lab of Linda Buck, winner of the 2004 Nobel Prize in Physiology or Medicine, for falsifying data in two papers written with the support of grants from the National Institutes of Health.
The researcher, Zou Zhihua, worked with Buck as a post-doc at Harvard and then at the Fred Hutchinson Cancer Research Center, in Seattle, Buck’s current home. After leaving there in 2005, he spent three years at the University of Texas Medical Branch in Galveston, and now appears to be a faculty member at Jilin University in China.
According to the report:
There has been another development in the case of Dong-Pyou Han, the former Iowa State University (ISU) researcher who admitted last fall to spiking rabbit blood samples to make it look as though his team’s HIV vaccine was working in the animals.
Melanie Pallansch-Cokonis, a former research technician at Southern Research Institute, faked data in work funded by NIH contracts and grants, according to the Office of Research Integrity (ORI).
“Misrepresentation,” “reckless disregard for basic scientific standards”: Hauser report reveals details of misconduct
Courtesy of a Freedom of Information Act request, The Boston Globe has a very good piece detailing what investigators found had actually happened in the Marc Hauser lab before the former Harvard psychology researcher resigned in 2011 and was found guilty of misconduct by the Office of Research Integrity (ORI) in 2012.
The Globe requested the 2010 report Harvard sent the ORI. Here’s a summary:
The 85-page report details instances in which Hauser changed data so that it would show a desired effect. It shows that he more than once rebuffed or downplayed questions and concerns from people in his laboratory about how a result was obtained. The report also describes “a disturbing pattern of misrepresentation of results and shading of truth” and a “reckless disregard for basic scientific standards.”
The Globe quotes key passages from the report: Read the rest of this entry »
We first wrote about Helen Freeman in February, when we covered a retraction in Cell Metabolism that said the UK’s Medical Research Council had found that she committed misconduct while working as a student at Oxford. Today, a Federal Register notice from the ORI reports that Freeman faked images in a manuscript submitted to Nature while she was working on federally funded grants at Harvard Medical School and Beth Israel Deaconess Medical Center.
fabricated the quantitative and qualitative data for RNA and DNA purportedly extracted from 900 formalin-fixed, paraffin-embedded (FFPE) colorectal tissue samples presented in Table 1 of the CEBP paper and falsely reported successful methodology to simultaneously recover nucleic acids from FFPE tissue specimens, when neither the extractions nor analyses of the FFPE samples were done. Thus, the main conclusions of the CEBP paper are based on fabricated data and are false.
A former postdoc at the Mount Sinai School of Medicine in New York faked data in four published papers, one submitted manuscript, and four NIH grant applications, according to new findings by the Office of Research Integrity.
We reported on six retractions from Savio Woo’s Mount Sinai lab in 2010, from the Proceedings of the National Academy of Sciences (PNAS), the Journal of the National Cancer Institute, and two each from Human Gene Therapy and Molecular Therapy. The PNAS paper, as we noted then:
claimed to have discovered a possible cure for phenylketonuria, or PKU, in mice—a finding that was cited more than 30 times and trumpeted in the media.
At the time, Mount Sinai said that two of the lab’s postdocs had been dismissed for misconduct. Now, more than three and a half years later, the ORI reports that a former postdoc in that lab, Li Chen: Read the rest of this entry »