Archive for the ‘ori investigations’ Category
A researcher who confessed to spiking rabbit blood samples to make the results of an HIV vaccine experiment look better has been sentenced to 57 months of prison time, according to The Des Moines Register.
Dong-Pyou Han has also been ordered to repay more than $7 million to the U.S. National Institutes of Health, and will have three years of supervised release following his prison term.
In December, 2013, the U.S. Office of Research Integrity announced that Han, formerly at Iowa State University (ISU), had faked his results to make an HIV vaccine look more powerful. The faulty data made their way into seven national and international symposia between 2010 and 2012 (resulting in a retracted poster in 2014), along with three grant applications and multiple progress reports. Han agreed to a three-year research ban, and resigned from ISU in October the following year.
The NIH never sent the final $1.38 million grant payment of more than $10 million awarded to Han’s boss, Michael Cho, and ISU returned nearly $500,000 it had received for Han’s salary and other costs.
However, Read the rest of this entry »
Two papers about the molecular underpinnings of lung damage are being retracted following an investigation at Oita University in Japan, which revealed that images from both papers had been used to depict “different experimental conditions” in a third paper (which has not been retracted).
It’s not clear which of the authors were the subject of the investigation. The two retracted papers, “Nafamostat mesilate inhibits the expression of HMGB1 in lipopolysaccharide-induced acute lung injury” in the Journal of Anesthesia and “Coexpression of HSP47 Gene and Type I and Type III Collagen Genes in LPS-Induced Pulmonary Fibrosis in Rats” in Lung, both originally published in 2007, share the same first author — Satoshi Hagiwara, whose affiliation is listed as the Department of Brain and Nerve Science, Anesthesiology, Oita University Faculty of Medicine. The papers have been cited 13 times and 12 times, respectively, according to Thomson Scientific’s Web of Knowledge. Hagiwara is also the first author on the third paper that contains the duplicated images.
The first retraction notice reads:
A former employee in the public health division of the Oregon Health Authority committed misconduct in 56 case reports about Clostridium difficile infections in Klamath County, Oregon, as well as in a manuscript submitted to JAMA Internal Medicine and a published report in the Morbidity and Mortality Weekly Report in March, 2012.
Ryan Asherin, previously a Surveillance Officer and Principal Investigator at the OHA, was a busy man. According to the details from a report by the U.S. Office of Research Integrity, Asherin:
The Journal of Neuroscience is retracting a 2012 paper on how estrogen produced in the brain shapes the auditory system on the basis of “a report from Northwestern University that describes substantial data misrepresentation” in the paper.
The paper, “Mechanistic Basis and Functional Roles of Long-Term Plasticity in Auditory Neurons Induced by a Brain-Generated Estrogen,” is, according to PubMed, the last one published by its last (and corresponding) author Raphael Pinaud, and first author Liisa Tremere, who were both at Northwestern University at the time. Before his position at Northwestern, Pinaud held positions at the University of Oklahoma and the University of Rochester.
Pinaud and Tremere jointly published a handful of papers on the role of estrogen in the auditory system of the brain starting in 2009, some of which are co-authored by two of the other researchers on the current paper, which has been cited 8 times, according to Thomson Scientific’s Web of Knowledge.
Here’s the retraction notice:
“[W]e can learn from these bad actors:” Trail of retractions follows former Vanderbilt researcher’s fraud
Authors have retracted three papers from the Journal of Physiology because they contained “falsified or fabricated data.”
The papers, which address calcium signaling in heart muscle cells, are among the six pegged for retraction after an Office of Research Integrity (ORI) investigation into one of the authors, Igor Dzhura, formerly of Vanderbilt University. The ORI found that Dzhura had committed an enormous amount of fraud, involving dozens of faked images and more.
Dzhura was fired from a job at Novartis in November after the company discovered that his application had included the fraudulent work.
The three retracted Journal of Physiology papers and their citation figures, courtesy of Thomson Scientific’s Web of Knowledge, are: Read the rest of this entry »
A University of Minnesota former chemistry graduate student has been banned from receiving federal funding for five years based on “a preponderance of the evidence that the Respondent intentionally and knowingly engaged in research misconduct.”
Venkata J. Reddy appears to have manipulated findings in one R01 grant application. In recent years, bans are less common than having research supervised. What’s also unusual is that the sanction appeared to have begun two years ago, in 2013, because it lifts August 26, 2018. The report, which is scheduled to published tomorrow in the Federal Register, says the debarment has a “joint jurisdiction,” suggesting another agency may be involved. [See first update at end of post.]
According to the ORI notice, Reddy “intentionally and knowingly engaged in research misconduct by falsifying and/or fabricating data that was provided to his mentor” for an R01 application to the National Institute of General Medical Sciences (NIGMS). More specifically: Read the rest of this entry »
Nasser Chegini, the former University of Florida professor currently under investigation by the Office of Research Integrity (ORI), has now had eight papers retracted.
The eighth paper, in the journal Reproductive Biology and Endocrinology, is about the effect of a compound used during fertility treatments on Smads, signaling molecules that carry messages from TGF-beta receptors to the nucleus. It’s being retracted disappeared due to the discovery of data that “have been fabricated or falsified by the last author” — namely, Chegini.
Here’s more from the notice for “Gonadotropin releasing hormone analogue (GnRHa) alters the expression and activation of Smad in human endometrial epithelial and stromal cells:” Read the rest of this entry »
Teresita Briones, a former nursing professor at Wayne State University in Detroit who studied neuroscience, manipulated images in five papers, according to the Office of Research Integrity.
Briones, who focused on neuroplasticity: Read the rest of this entry »
Ryousuke Fujita, a former Columbia University postdoc who admitted to having faked the findings of a 2011 Cell paper in a retraction notice last year, also faked the results of a 2013 Nature paper, according to a new report from the Office of Research Integrity (ORI).
Fujita’s work, in conjunction with Asa Abeliovich, was widely hailed as a significant step forward, a way to turn skin cells into brain cells. But the story began falling apart when the Cell retraction said that he “acknowledged inappropriately manipulating image panels and data points, as well as misrepresenting the number of repeats performed.”
The ORI’s findings in the case also involve a 2013 Nature paper, “Integrative genomics identifies APOE ε4 effectors in Alzheimer’s disease,” and a paper never published. Fujita, according to the ORI: Read the rest of this entry »
Two more retractions have popped up for Nasser Chegini, the former University of Florida professor currently under investigation by the Office of Research Integrity (ORI).
Both retractions appear in the Journal of Clinical Endocrinology & Metabolism. The notices indicate that an investigation report from the University of Florida “found substantial data misrepresentation” in two JCEM articles about Smads, signaling molecules that carry messages from TGF-beta receptors to the nucleus.
Here’s the notice for “The Expression of Smads in Human Endometrium and Regulation and Induction in Endometrial Epithelial and Stromal Cells by Transforming Growth Factor-Beta” ( ):