Retraction Watch

Tracking retractions as a window into the scientific process

Archive for the ‘thrombosis and haemostasis’ Category

Our computer ate the data: Expression of concern over blood thinner study raises concerns itself

without comments

Thrombosis and Haemostasis has issued an “expression of concern” over a 2004 paper by Tunisian researchers:

Concerns have been raised by readers about the accuracy and validity of the data reported in the September 2004 article by Abdelkefi et al., entitled “Prevention of central venous line-related thrombosis by continuous infusion of low-dose unfractionated heparin, in patients with haemato-oncological disease. A randomized controlled trial” (Abdelkefi A et al.Thromb Haemost 2004; 92: 654–661).

In the trial, 108 patients with blood cancers reportedly received infusions of either saline or heparin, a blood thinner. Those given the active drug were far less likely to develop clots related to their catheters, according to the researchers, and no more likely to experience severe bleeding. In the report, the researchers write:

This is the first prospective, randomized study, which shows that low-dose of unfractionated heparin is safeand effective to prevent catheter-related thrombosis in patients with haemato-oncological disease.

The article has had an impact, having been cited 32 times, according to Thomson Scientific’s Web of Knowledge. At some point after publication, however, the results evidently began to look fishy. Again from the journal: Read the rest of this entry »