Edward J. Fox, a former faculty member at the University of Washington in Seattle, faked data in a manuscript submitted to Nature and in an NIH grant application, according to new findings from the U.S. Office of Research Integrity (ORI).
Fox, who initially confessed to some of the misconduct when confronted by the university, “neither admits nor denies ORI’s finding of research misconduct related to grant application R01 CA193649-01A1,” the ORI said in an announcement. However, he
acknowledges that his research records were poorly maintained and lacked the documentation necessary to support the reported preliminary results.
Fox, according to the ORI,
engaged in research misconduct by intentionally, knowingly, or recklessly:
- fabricating data and analyses in a manuscript submitted to Nature, which was subsequently voluntarily withdrawn. These fabricated data and analyses also appear in Figure 1 of grant progress report R01 CA193649-02. Respondent stated during the inquiry that two abstracts that appear in Cancer Research are based on the fabricated data and analyses.
fabricating or falsifying data and analyses in the preliminary results section of grant application R01 CA193649-01A1, section C.1.a(iv).
For example, Fox faked data in two figures
to show that the frequency of unique subclonal mutations in normal cells increases as people age, while the frequency of subclonal mutations in cancerous cells does not
and in another figure
to show a pattern of subclonal mutations for the fabricated data from Figures 1c and 1d and fabricated the statistical analysis results to show statistically significant differences between tumor and normal mucosa…
Fox — who agreed to a year of supervision for any federally funded research — did not respond to a request for comment.
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