Archive for the ‘pathology’ Category
An investigation into a scientist suing PubPeer commenters over criticisms of his work has concluded that the researcher engaged in widespread misconduct and should retract 42 papers.
The investigation report by Wayne State University, obtained by The Scientist, reveals that Fazlul Sarkar created a research environment that encouraged productivity but cut corners when it came to integrity: Read the rest of this entry »
It’s not often that a paper elicits an apology — but that’s just what happened when family members first learned a bagpipe musician died from inhaling mold and fungi from a case study reported in a journal. The hospital has since apologized; the journal, however, told us it is not planning to issue a retraction.
The University Hospital of South Manchester NHS Foundation Trust in Wythenshawe, UK, has apologized and launched an internal investigation into the case report after the family’s distress was extensively covered by the UK’s mainstream media, such as The BBC, The Independent, The Daily Mail, and The Telegraph.
There seem to be conflicting accounts over whether any consent was obtained to publish the report. The Thorax paper says the patient gave consent, and according to Gisli Jenkins, co-editor-in-chief of the journal and a professor of experimental medicine at Nottingham University in the UK, consent was sought from the family. But the patient’s daughter told us that neither the next of kin nor the patient were approached for consent.
The release of the report on August 22 was “completely unethical,” said Erin Tabinor, daughter of musician Bruce Campbell and a makeup artist in Liverpool, UK. Tabinor told us that the family wasn’t aware that playing bagpipes was the cause of Campbell’s death: Read the rest of this entry »
A U.S. judge has denied a virology researcher’s third attempt to overturn a seven-year debarment from receiving federal funds, following a 2010 decision by the U.S. Office of Research Integrity.
The ORI banned Scott Brodie for seven years after concluding he had committed 15 acts of misconduct at the University of Washington. The deception affected grant applications, published papers, manuscripts, and presentations. Since then, Brodie has tried multiple times to reverse the ruling in court.
He’s also earned his fourth retraction. The new notice, along with one we’ve uncovered from 2014, provide some information on the extent of the deception of Robert Frumento, who left Columbia a decade ago, around the time that the now-retracted papers were published.
Here’s the new retraction notice:
Authors have retracted a pair of PLOS ONE papers after an investigation suggested the articles might contain some fiction.
In the papers, the authors describe collecting and analyzing the DNA of mosquitoes to look for changes following the introduction of bed nets treated with insecticides to combat malaria. However, an investigation by the Institut de Recherche pour le Développement in France could not confirm some of the experiments ever took place.
Here’s the retraction notice for “How the Malaria Vector Anopheles gambiae Adapts to the Use of Insecticide-Treated Nets by African Populations,” which appears at the top of the paper:
Retracted this month — less than three months after it was published — the paper showed, according to a summary on the cover page:
B. subtilis is a symbiont that resides in the gut of C. elegans and generates nitric oxide that is essential for the host. Xiao et al. demonstrate that nitric oxide promotes defense against pathogenic bacteria by activating p38 MAPK, demonstrating the importance of commensal bacteria in host immunity.
But B. subtilis — a member of the Bacillaceae family — aren’t actually as plentiful as they appeared, explains the retraction notice for “Gut-Colonizing Bacteria Promote C. elegans Innate Immunity by Producing Nitric Oxide:”
Readers likely know by now how easy it is for this to happen, as we frequently report on retractions due to similar reasons. Like other instances of mistaken cell identity, the authors of this 2013 paper realized the mistake following further tests of the bacteria used in the experiment.
Authors have pulled a paper on an antifungal drug that is potentially toxic because it lacked final approval from their institution.
The study describes a patient who had experienced liver toxicity after taking voriconazole. During the study, the authors re-administered the drug to the patient using “a slow dose titration.” But their institution didn’t approve the study before it was published online.
Here’s the retraction note for “Successful Rechallenge with Voriconazole following Medication-Induced Hepatotoxicity,” published in Antimicrobial Agents and Chemotherapy. Read the rest of this entry »
We don’t have a lot of information on a recent retraction of a 2001 paper published in a Japanese journal — just a brief and strongly worded note explaining that it follows “a strict, extensive, and judicious review.”
The paper, retracted 14 years after it was published, describes patients in Okinawa, Japan who developed severe symptoms following infection by bacteria belonging to the Aeromonas genus. One example:
The one patient was a 15-year-old high school girl student, who had been healthy in her school life, was admitted to the hospital with a sudden onset of left thigh muscle pain and swelling. She subsequently went into septic shock and died one day after admission. Pathological examination on autopsy revealed massive gas formation, skin bullas and ulcers, and extensive severe soft tissue damage throughout the body.
“Aeromonas species infection with severe clinical manifestation in Okinawa, Japan-association with gas gangrene” has been cited three times, according to Thomson Scientific’s Web of Knowledge. It was published in a Japanese journal, Rinsho Biseibutshu Jinsoku Shindan Kenkyukai Shi — which translates to the Journal of the Association for Rapid Method and Automation in Microbiology.
A Toronto hospital network is keeping two researchers’ labs closed even after an Ontario court quashed part of a misconduct finding by the institution.
Some background: After the University Health Network found evidence of falsified data, Sylvia Asa stepped down as Program Medical Director of the Laboratory Medicine Program, the largest hospital diagnostic laboratory in Canada. Due to the investigation, UHN suspended the labs of Asa and her husband Shereen Ezzat. In response, Asa and Ezzat asked an Ontario court to quash the misconduct findings; last month, the court overturned two out of three findings, and asked UHN to reconsider its sanction against the pair.
According to the Toronto Star, on February 4th the UHN notified the researchers that the sanction against them would be upheld, and it would not reopen the researchers’ labs.
The Star spoke to the researcher’s lawyer, Brian Moher who Read the rest of this entry »