Retraction Watch

Tracking retractions as a window into the scientific process

Archive for the ‘molecular biology’ Category

3rd retraction appears for fired Pfizer breast cancer researcher

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Pfizer has retracted a paper by a former employee who was fired after the company discovered she had been doctoring data.

The retraction, in Molecular Cancer Research, is the third of five papers Pfizer asked to retract, after an investigation discovered they contained duplicated images. The papers have been discussed on PubPeer, which is also mentioned in the latest retraction notice.

As a result of the investigation, Pfizer terminated the employment of Min-Jean Yin, the last author on the newly retracted paper.

According to the notice, Yin and five of her co-authors agreed to the retraction:

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Unexplained abnormalities in stem cells prompt Columbia researchers to pull diabetes paper

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Researchers at Columbia University have retracted a 2013 paper in The Journal of Clinical Investigation, after uncovering abnormalities in the stem cell lines that undermined the conclusions in the paper.

Last year, corresponding author Dieter Egli discovered he could not reproduce key data in the 2013 paper because almost all the cell lines first author Haiqing Hua used contained abnormalities, casting doubt on the overall findings. When Egli reached out to Hua for answers, Hua could not explain the abnormalities. As a result, Hua and Egli agreed the paper should be retracted.

Since some of the details of how the paper ended up relying on abnormal cells remain unclear, the university confirmed to us that it is investigating the matter.

Here’s the retraction notice for “iPSC-derived β cells model diabetes due to glucokinase deficiency,” cited 42 times: Read the rest of this entry »

Cancer biologist stops research as his retraction count rises to 13

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Anil Jaiswal

A cancer biologist based at the University of Maryland is transitioning out of research, as a journal has retracted three more of his papers.

Anil Jaiswal has now lost 13 papers, including, as we reported on February 6, six retractions issued earlier this month.

The Baltimore Sun reported this week that Jaiswal would no longer be conducting research at the University of Maryland School of Medicine, which we confirmed from a spokesperson:

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Authors pull virus replication paper after they cannot replicate results

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Researchers in China have retracted a 2016 paper exploring the replication behaviors of a retrovirus, after discovering that the key results could not be reproduced — possibly because their cell cultures had been contaminated.

The authors also cite a disagreement with a colleague, who they say contributed to the work but does not want to be listed as an author.

Here’s the retraction notice for “Nuclear import of prototype foamy virus transactivator Bel1 is mediated by KPNA1, KPNA6 and KPNA7,” published in the International Journal of Molecular Medicine: Read the rest of this entry »

Journal pulls paper with missing data, citing inquiry and legal proceedings

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A journal has retracted a 2012 paper after the last author was unable to provide material to support the results presented in multiple figures.

The lack of supporting data came out during “an internal inquiry and subsequent legal proceedings,” according to the notice, issued by Cell Cycle.

The last author on the paper is Susana Gonzalez, who was dismissed from her position at the National Center for Cardiovascular Research (CNIC) in Spain last year.

Here’s the full notice:

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Students withdraw report of private stem cell retreat

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Master’s students have retracted a review of an internal meeting of stem cell researchers because it contained confidential information.

According to the Managing Director of the society, Stem Cell Network North Rhine Westphalia (NRW), the event was not open to the public, and the authors had not contacted either the society or the scientists they cited before publishing the report.

Here’s the retraction notice for “A Report on the Internal Retreat Meeting of the Stem Cell Network North Rhine Westphalia,” published online in Molecular Biotechnology on October 31 and retracted shortly after on December 14: Read the rest of this entry »

Columbia University probe prompts retraction of cardiovascular paper

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A journal has retracted a 2011 study at the request of Columbia University.

According to Jeanine D’Armiento, the study’s last author, the newly retracted paper in Clinical Science contained a figure from a Journal of Hypertension paper published by the same authors earlier that year. 

First and corresponding author Joseph George told Retraction Watch the error was unintentional. A Columbia spokesperson sent us this statement: Read the rest of this entry »

Journal retracts paper due to image mismatch; one co-author alleges fraud

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Researchers have retracted a biology paper that included an image mismatch — despite the fact that, as they claim, another image in the same paper confirms the original findings.

The authors say they plan to resubmit the paper with the corrected figure panel.

The second to last author — Carlo Croce, chair of the department of cancer biology and genetics at The Ohio State University — told us he believes there’s more to the retraction than what the notice says. Specifically, he said that the paper includes an image from a previous paper by the same authors, which he called “fraud.”

Here’s the latest retraction notice, published in Cell Death and Differentiation:

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Surgery chair who blamed image issues on software logs three more retractions

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A researcher who claimed image problems in a retracted paper were the result of a software glitch, and not intentional, has lost three more papers — all for image manipulation.

In two notices, the Journal of Biological Chemistry specifies that duplicated images were used to represent different experimental conditions; one notice simply says the paper was affected by image manipulation.

All of the notices specify the papers are being retracted by the publisher, the American Society for Biochemistry and Molecular Biology — which this month published a set of recommendations for preparing a paper, including how to avoid excessive manipulation.

The papers were published between 2002 and 2010, and all share the same last author (Paul Kuo, currently chair of surgery at Loyola Medicine) and first author (Hongtao Guo, at Duke).

Here’s the first notice:

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A Harvard whistleblower was subjected to a forced mental exam. Here’s why.

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Last March, a PhD student at Harvard filed a misconduct allegation against his mentor, a prominent stem cell researcher. Three months later, he was taken from his home by police in the middle of the night for a forced psychiatric evaluation.

How did this happen? Read the rest of this entry »