Retraction Watch

Tracking retractions as a window into the scientific process

Archive for the ‘molecular biology’ Category

“The paper is extremely flawed:” Journal retracts article linked to vaccines

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A journal has retracted a 2016 paper after receiving criticism from outside researchers who raised concerns about its methodology and data.

The paper shares multiple authors with another paper that linked the vaccine for human papillomavirus (HPV) to behavioral problems in mice. Last year, a journal removed the study; later that year, the authors published a revised version in another journal. The latest retracted paper focuses on the antibodies present in a form of lupus.

Yehuda Shoenfeld at Tel-Aviv University in Israel, the corresponding author on both this latest retraction and the HPV vaccine paper, recently edited a textbook that explored how vaccines can induce autoimmunity in some people.  He told us the 2016 lupus paper does have a link to vaccines [his emphasis]:

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Journal corrects paper by researcher sanctioned for misconduct

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A biology journal has issued a correction to a 2014 paper by a researcher with 11 retractions, citing “inadvertent errors” that don’t affect the conclusions.

The researcher, Rony Seger, was recently sanctioned by his institution (The Weizmann Institute in Israel) following a finding of “serious misconduct” involving data manipulation. Specifically, the institute barred him from supervising graduate students, even future ones; his lab is now dedicated to replicating his previous work, with the help of a technician.

Last month, Michal Neeman, vice president of The Weizmann Institute of Science, told us she wasn’t sure how many additional papers by Seger would need to be retracted or corrected.

Recently, one more was revealed — in the August issue of Molecular and Cellular Biology, the following correction notice appears:

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Scientist steps down from South Korea government position over criticism of her role in stem cell scandal

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A professor at Sunchon National University has resigned from a prominent government position in South Korea after facing heavy criticism for being a co-author of a fraudulent stem cell paper.

Earlier this week, President Moon Jae-in appointed Park Ky-young to run a newly created Science, Technology and Innovation Office at the Ministry of Science and ICT. Critics quickly cried foul, noting that Park co-authored one of the stem cell papers by Woo-Suk Hwang, which made headlines 10 years ago after an investigation revealed the supposedly groundbreaking research had been fabricated.

According to the Korea Herald, Park’s position would have given her a say over the country’s R&D budget, worth 20 trillion won ($17 billion USD) in the science sector. The appointment does not require approval from parliament.

Today, Park agreed to step down. In a written statement, she said:

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Written by Alison McCook

August 11th, 2017 at 8:30 am

Third retraction for former rising star found guilty of misconduct

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A once-prominent researcher in the field of infectious disease — who was found guilty of misconduct last year— has had a third paper retracted, a 2006 article in PNAS.

Last year, the University of Dundee in Scotland found that Robert Ryan had committed research misconduct, which included misrepresenting clinical data and duplicating images in a dozen different publications. After a failed attempt to appeal the decision, Ryan resigned.

In April, we covered Ryan’s first two retractions – a 2012 paper in Molecular Microbiology, which cited image errors, and a 2011 paper in Journal of Bacteriology, which cited image duplication.

Now, PNAS has retracted a 2006 paper, which cites potential image duplication as well as “irregularities” in the data.

Here’s the retraction notice for “Cell–cell signaling in Xanthomonas campestris involves an HD-GYP domain protein that functions in cyclic di-GMP turnover:”

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After investigation that started at least 5 years ago, retired ob-gyn prof agrees to 5 years of supervision

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Nasser Chegini

A now-retired professor tweaked the findings in seven figures of a 2007 paper, according to a new finding of misconduct released yesterday by the U.S. Office of Research Integrity.

The subject of the findings isn’t a stranger to our readers: We’ve already reported on nine retractions for Nasser Chegini, a former professor of obstetrics and gynecology at the University of Florida (UF) who had won more than $4 million in Federal grants. And Chegini, who retired in early 2012, had been under investigation since at least 2012, with the ORI asking UF to broaden that investigation at one point.

Indeed, the ORI’s notice states that eight of Chegini’s retractions resulted from the UF’s investigation. The ORI’s findings, however, stem from another paper, published in the Journal of Reproductive Immunology, which has not been retracted.

According to the ORI, in that paper, Chegini:

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Why did it take a journal two years to retract a paper after a misconduct finding?

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A 2014 paper containing data manipulated by a former graduate student has finally been retracted, two years after the U.S. Office of Research Integrity (ORI) published its findings.

In August 2015, the ORI published a report that Peter Littlefield, who was working on his PhD at the University of California, San Francisco (UCSF), had committed “research misconduct by falsifying and/or fabricating data” in two papers. Littlefield agreed to correct or retract the papers–one published in Chemistry & Biology and the other in Science Signaling.  

When we contacted Chemistry & Biology back in August 2015, a spokesperson for Cell Press told us the journal was figuring out “the best way to correct the scientific record.”

Apparently that took two years. In the meantime, the journal did not issue an expression of concern or otherwise notify readers of the issues. Read the rest of this entry »

Nature retracts paper by stem cell scientist appealing her dismissal

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Susana Gonzalez

A once-rising star in stem cell biology — who recently lost both her job and a sizable grant — has had a fourth paper retracted.

The notice — issued by Nature for a 2006 letter — cites duplicated images, and a lack of raw data to verify the findings. First author Susana Gonzalez — who was dismissed from her position at the National Center for Cardiovascular Research (CNIC) in Spain last February over allegations of misconduct — couldn’t be reached by the journal.

Here’s the full text of the retraction notice:

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The retraction countdown: How quickly do journals pull papers?

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After Tina Wenz was found guilty of scientific misconduct, how long did it take for journals to retract the problematic papers?  The answer: Between three and nine months.

In September 2016, the University of Cologne found that Wenz had committed scientific misconduct in six papers and requested they all be retracted. From that point on, the retraction clock was ticking.

We’ve explored how long it takes a journal to act over the years, and we’ve found that the time between identifying a problem to retracting the paper can vary — and sometimes last years.

In Wenz’s case, one of the papers—published in Cell Metabolism in 2009—had already been retracted in 2015. Three of the remaining five were retracted in December 2016—a 2008 paper in Cell Metabolism, a 2009 paper in Proceedings of the National Academy of Sciences (PNAS), and a 2009 paper in the Journal of Applied Physiology.

In January 2017, the journal IUBMB Life pulled a 2014 paper flagged in the investigation. And just over nine months after Wenz was found guilty of misconduct, the last paper—published in 2013 in Mitochondrion—has been retracted.

The most recent notice states that the University of Cologne requested the retractions, after determining that the data had been “inappropriately manipulated.”

Here’s the retraction notice in Mitochondrion:

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Fake peer review, forged authors, fake funding: Everything’s wrong with brain cancer paper

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The paper had everything: Fake peer review, forged authors, even a fake funder.

In other words, it had nothing.

A 2015 paper is the latest retraction stemming from an investigation into fake peer review by Springer, which has now netted more than a hundred papers.

According to a spokesperson at Springer: Read the rest of this entry »

Cancer paper retracted after author discovers signs of data manipulation

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A molecular biology journal has retracted a 2017 cancer paper only two months after it appeared online, after the corresponding author notified the journal about possible data manipulation.

According to the notice, Chunsun Fan, from Qidong Liver Cancer Institute & Qidong People’s Hospital in China, requested the retraction after finding “signs of data manipulation” in the paper that was published online in April. The journal, FEBS Letters, acted quickly, publishing a retraction earlier this month.

Here’s the retraction notice for “MiR-19 regulates breast cancer cell aggressiveness by targeting profilin 1:” Read the rest of this entry »