Archive for the ‘molecular biology’ Category
Last March, a PhD student at Harvard filed a misconduct allegation against his mentor, a prominent stem cell researcher. Three months later, he was taken from his home by police in the middle of the night for a forced psychiatric evaluation.
How did this happen? Read the rest of this entry »
Gearóid Ó Faoleán, ethics and integrity manager at Frontiers, which publishes Frontiers in Plant Science, told us:
In accordance with our complaints protocol, the Field Chief Editor led the investigation that resulted in the decision to retract the paper.
In 2011, authors of a Nature letter caught some flak for issuing a lengthy correction to a neuroscience paper that had raised eyebrows within days of publication — including some suggestions it should be retracted.
The correction notice, published months after the original letter, cited errors in image choice and labeling, but asserted the conclusions remained valid.
Now, those conclusions appear up for debate. In a recent Nature Brief Communications Arising (BCA) article, a team that raised concerns about the paper five years ago says they are unable to reproduce the results. But the authors of the original paper aren’t convinced: They argue that the BCA fails to cite important evidence, has a “complete absence or low quality of analysis,” and the scientists disregard some of their data.
Four of the newly corrected papers have a common last and corresponding author: Luke O’Neill of Trinity College Dublin in the Republic of Ireland. O’Neill is also a co-author of the remaining paper that was fixed. O’Neill told us the mistakes were a “bit sloppy,” noting that he takes responsibility for the errors in the four papers on which he is last author.
O’Neill forwarded Retraction Watch a comment he received from Kaoru Sakabe — data integrity manager at the American Society for Biochemistry and Molecular Biology (which publishes The Journal of Biological Chemistry (JBC)) — that reads: Read the rest of this entry »
According to the retraction notice in the International Journal of Molecular Medicine (IJMM), the authors intended that the two different papers offered “different research perspectives.”
Meanwhile, the Chinese Medical Journal — which published the same images one month later — has issued an expression of concern (EOC), noting it “should not be considered as a statement regarding the validity of the work.” Both papers describe how cells regulate blood flow to the retina.
Normally, journals choose to retract the most recent paper containing duplicated images, but in this case, the IJMM paper was published online in February 2016, and the Chinese Medical Journal in March.
In November, a vice president at an institution in Taiwan retracted a hotly debated cancer paper from Nature Cell Biology, citing image problems including duplications. Now, the Journal of Biological Chemistry has done the same, again citing image duplications.
There are a few things to note about the latest retraction: One, the last author is again Kuo Min-liang — who holds an appointment at National Taiwan University (NTU), and is also a vice president at Kaohsiung Medical University in Taiwan. Kuo is currently facing allegations that he accepted bribes to add co-authors to his papers; NTU told us it is investigating the latest retraction in the Journal of Biological Chemistry, including Kuo.
The other notable feature of the retraction is the notice itself, which lists a remarkable number of duplicated images. Take a look:
The latest retraction for Tina Wenz in the Journal of Applied Physiology mentions the probe at the University of Cologne in Germany, which recommended retracting six of her papers. One had already been retracted by the time the report was released; last month, we reported that two others had been pulled. Now, we’ve come across a fourth.
Following a journal probe and questions on PubPeer about their work, authors in Spain have issued four corrections, citing missing raw data for experiments conducted more than 10 years ago.
All papers include the same last two authors, Mireia Duñach at the Autonomous University of Barcelona, and Antonio García de Herreros at the Institut Hospital del Mar d’Investigacions Mèdiques.
Three of the corrections were issued by the Journal of Biological Chemistry, from which the authors retracted three papers earlier this year after a journal investigation concluded they contain reused images, designed to represent different experiments.
Duñach told us the latest corrections are the result of her own initiation:
2013 probably felt like it was going to be a great year for stem cell biologist Douglas Melton at Harvard. He had published a buzz-worthy paper in Cell about a new way to potentially boost insulin in diabetics, attracting significant media attention, and eventually gathering nearly 200 citations.
But 2016 is closing out on a less positive tone for Melton — today, he and his colleagues are retracting the paper, after multiple labs (including his own) couldn’t reproduce the findings.
Although the lab has itself already published two articles casting doubt on the original findings, Melton told Retraction Watch he chose to retract the paper to ensure there was no confusion about the original paper’s validity: Read the rest of this entry »
A researcher in Brazil is taking responsibility for accidentally mixing up images in three papers in the Journal of Biological Chemistry.
The corresponding author on the three papers told us the mistake happened because the studies were conducted simultaneously, and relied on one computer.
There’s a side note to these retractions: The co-author list on two papers includes names that should be fairly well-known to our readers — Mario Saad, the researcher who unsuccessfully sued the American Diabetes Association to stop retractions of his papers, and Rui Curi, a researcher whose legal threats assisted in the shutdown of Science-Fraud.org. This makes Saad’s ninth retraction.
According to the retraction notices, Lício Velloso — who, like his co-authors, is based at the University of Campinas in São Paulo, Brazil — assembled all the figures. He told Retraction Watch that the authors initially wanted to correct the papers, adding: Read the rest of this entry »