Archive for the ‘not reproducible’ Category
The Journal of the American Chemical Society has retracted a 2009 paper on ethylene polymerization after the authors said they were unable to replicate their findings.
The article, “Bimetallic Effects for Enhanced Polar Comonomer Enchainment Selectivity in Catalytic Ethylene Polymerization,”came from the lab of Tobin Marks, a highly decorated — and grant-and-royalty-generating — chemist at Northwestern University.
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The article, “Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK,” came from the lab of Jef Boeke, a celebrated biochemist. But a former lab member, Daniel Yuan, who was fired by Hopkins in late 2011 after 10 years at the institution, had repeatedly raised questions about the validity of the findings. Those concerns eventually made their way into the Washington Post, prompting this response from the university. Read the rest of this entry »
Two American College of Cardiology conference abstracts published earlier this year in the Journal of the American College of Cardiology (JACC) have been retracted, one because the authors were actually measuring something other than what they reported, and the other because newer software invalidated the results.
Here’s the notice for “Worsening of Pre-Existing Valvulopathy With A New Obesity Drug Lorcaserin, A Selective 5-Hydroxytryptamine 2C Receptor Agonist: A Meta-Analysis of Randomized Controlled Trials” by Hemang B. Panchal, Parthav Patel, Brijal Patel, Rakeshkumar Patel, and Henry Philip of East Tennessee State University: Read the rest of this entry »
A team of researchers led by Daniel St. Johnston, director of the Gurdon Institute at Cambridge and a prominent developmental biologist in the UK, has lost a pair of articles after finding that their data were unreliable. But rather than “correct” the record with subsequent papers, they’ve withdrawn the problematic work.
To our mind, this is a poster case of doing the right thing by science. We think the notices — as provided by the authors and reported by the journals — pretty much say it all, so we’ll let them speak for themselves, followed by some details St. Johnston shared with us.
The first article, “LKB1 and AMPK maintain epithelial cell polarity under energetic stress,” appeared in 2007 in the Journal of Cell Biology and has been cited 108 times, according to Thomson Scientific’s Web of Knowledge.
According to the retraction notice:
Ariel Fernández, the protein researcher whose theories of drug design lately have come in for questioning, has lost a paper, at least for the moment.
The article, “Supramolecular Evolution of Protein Organization,” appeared online in Annual Reviews of Genetics prior to print. It lists Fernández’s affiliation as ProWD Sciences, in Madison, Wisc. Not much exists on the web about that company, however, except an under-construction site. (ProWD, by the way, is short for PROtein-Water-Dehydron, Fernández’s area of interest.)
About a month ago, we reported on a retraction by Pamela Ronald, of the University of California, Davis, and colleagues. We noted then that this was a case of scientists doing the right thing. Ronald contacted us after that post ran, and let us know that there would be another retraction shortly. That retraction notice has now appeared, in Science: Read the rest of this entry »
The paper, “Derivation and Genetic Modification of Embryonic Stem Cells from Disease-Model Inbred Rat Strains,” came from the lab of Aron Geurts, of the Medical College of Wisconsin.
A materials scientist in Turkey has retracted a paper in the journal Tetrahedron after realizing that there was more to the compounds he was studying than he thought.
The article, “Novel donor–acceptor type thiophene pyridine conjugates: synthesis and ion recognition features,” appeared in April and was written by Fatih Algi, of the Laboratory of Organic Materials at Canakkale Onsekiz Mart University.
Last month, we reported on a retraction in Judgment and Decision Making that said “problems were discovered with the data.” At the time, corresponding author Wen-Bin Chiou, of National Sun Yat-sen University in Taiwan, told us that a research assistant who had since left the lab hadn’t kept questionnaires used in the research, making replication impossible.
But it turns out that wasn’t the whole story of “Shame for money: Shame enhances the incentive value of economic resources,” to put it charitably. We’ve now heard from people familiar with the case and can provide a fuller account.
The problems with the paper, according to our source, Read the rest of this entry »
The corresponding author of a paper on whether “a sense of shame heightens the desire for money” has retracted it, he claims, after being unable to repeat his analysis to try to fix an issue in the study.