Retraction Watch

Tracking retractions as a window into the scientific process

Archive for the ‘erroneous data’ Category

Journal knew about problems in a high-profile study before it came out — and did nothing for over a month

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In June, Gene Emery, a journalist for Reuters Health, was assigned to write a story about an upcoming paper in the Journal of the American College of Cardiology, set to come off embargo and be released to the public in a few days. Pretty quickly, he noticed something seemed off.

Emery saw that the data presented in the tables of the paper — about awareness of the problem of heart disease among women and their doctors — didn’t seem to match the authors’ conclusions. For instance, on a scale of 1 to 5 rating preparedness to assess female patients’ risk (with 5 being the most prepared), 64% of doctors answered 4 or 5; but the paper said “only a minority” of doctors felt well-prepared (findings echoed in an accompanying press release). On Monday June 19, four days before the paper was set to publish, Emery told the corresponding author — C. Noel Bairey Merz, Medical Director of the Women’s Heart Center at Cedars-Sinai in Los Angeles — about the discrepancy; she told him to rely on the data in the table.

But the more Emery and his editors looked, the more problems they found with the paper. They alerted the journal hours before it was set to publish, hoping that was enough to halt the process. It wasn’t.

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“The paper is extremely flawed:” Journal retracts article linked to vaccines

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A journal has retracted a 2016 paper after receiving criticism from outside researchers who raised concerns about its methodology and data.

The paper shares multiple authors with another paper that linked the vaccine for human papillomavirus (HPV) to behavioral problems in mice. Last year, a journal removed the study; later that year, the authors published a revised version in another journal. The latest retracted paper focuses on the antibodies present in a form of lupus.

Yehuda Shoenfeld at Tel-Aviv University in Israel, the corresponding author on both this latest retraction and the HPV vaccine paper, recently edited a textbook that explored how vaccines can induce autoimmunity in some people.  He told us the 2016 lupus paper does have a link to vaccines [his emphasis]:

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Author “shocked” after top math journal retracts paper

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One of the world’s most prestigious mathematics journals has issued what appears to be its first retraction.

The Annals of Mathematics recently withdrew a 2001 paper exploring the properties of certain symmetrical spaces.

What prompted this retraction? And why did it occur 16 years after the paper was published? Read the rest of this entry »

Written by Victoria Stern

July 12th, 2017 at 8:00 am

Lancet retracts (and replaces) paper a year after authors report error that changes “all numbers”

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In March 2016, researchers in Switzerland and Canada published a meta-analysis in The Lancet, exploring the optimal painkiller and dose for treating pain in knee and hip osteoarthritis. Soon after, the authors were informed of an error that would change “all numbers” in a paper that may influence clinical practice.

The authors contacted The Lancet immediately, in July 2016, to inform them of the issue. Sven Trelle, the paper’s corresponding author, also told us: Read the rest of this entry »

Written by Victoria Stern

July 10th, 2017 at 11:02 am

Big corrections usually weaken findings. But a recent NEJM one strengthened them, author says

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A 2016 study in New England Journal of Medicine has received a substantial correction, which affected several aspects of the article.

Typically, an error that affects so much of a paper would undermine the results (and possibly lead to a retraction). But in this case, the revised dose calculations actually strengthened the findings, according to the first author.

The NEJM study aimed to clarify whether patients with a neuromuscular disease called myasthenia gravis benefit from a surgical procedure to remove the thymus. About half of the patients received surgery plus the steroid prednisone, while the rest only received the steroid. The researchers found patients who received the surgery fared better.

Shortly after the paper was published in August 2016, the authors discovered an error in the calculation of the average prednisone dose. According to Gil Wolfe, the first author of the paper, when the researchers corrected the error: Read the rest of this entry »

“Authors’ negligence” causes “a plethora of data errors”

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Sometimes, even a short notice catches our attention.

Such was the case with a recent retraction issued by Oncotarget for a 2016 paper related to the genetics that drive cancer.

Here’s the notice:

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Rutgers prof announces retraction on his blog

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A Rutgers computer scientist is retracting conference proceedings via an unusual channel: his personal blog.

On April 7, Anand Sarwate wrote that he was retracting a mathematical proof from the proceedings from the 2016 IEEE International Conference on Acoustics, Speech, and Signal Processing (ICASSP), after discovering errors that invalidated the result.

He explains in the blog post why the mistake occurred:

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Researchers mistakenly administer three-fold higher dose of anesthesia

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Researchers have retracted a 2016 paper after discovering that they accidentally administered three times the reported dose of anesthesia to rats.

In the Experimental Physiology paper, the authors set out to mathematically map how rats’ blood pressure changes under different conditions, which required the rats to be anesthetized. But their findings were called into question when they found the rats had received a much higher concentration of anesthesia than intended. According to the notice, this higher dose compromised the “objectives of the experiment.”

The corresponding author Karol Ondrias, from the Institute of Molecular Physiology and Genetics at the Slovak Academy of Sciences in Bratislava, told us how the dosing error occurred: Read the rest of this entry »

Journals retract paper, flag two others by cancer doc under investigation

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Carlo Croce

This weekend, Carlo Croce had some reprieve from the misconduct accusations that have followed him for years (recently described in a lengthy article in the New York Times) and that have prompted his university to re-open an investigation. On Sunday, he received a prestigious award from the American Association for Cancer Research, honoring his work.

But the moment may have been short-lived. Today, Croce received two expressions of concern (EOCs) from PNAS for two well-cited papers published over a decade ago, on which Croce — chair of the Department of Cancer Biology and Genetics at The Ohio State University (OSU) — is last author. The two EOCs cite concerns over duplicated bands. What’s more, another journal recently decided to retract one of his papers, citing figures that didn’t represent the results of the experiments.

PNAS chose to issue EOCs, rather than retractions or corrections, because the authors didn’t agree that the bands were duplicated, according to executive editor Diane Sullenberger. She explained how the journal learned of the issues with the two papers: Read the rest of this entry »

Scientist who sued university earns two more retractions, bringing total to five

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A scientist who sued his employer for millions of dollars has earned two more retractions, for papers that had already been flagged by the journal.

By our count, Rakesh Kumar now has five retractions and multiple corrections.

Kumar sued his employer, George Washington University, for $8 million, alleging emotional distress when they put him on leave from his position as department chair following a finding of misconduct. That suit was settled last year, for undisclosed terms.

The two newest retractions in the Journal of Biological Chemistry — which tagged the papers with Expressions of Concern last year — both state that, according to Kumar, the problematic figures were assembled by “specific co-authors” — unnamed — in his lab. Here’s the first notice:

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