Archive for the ‘nature publishing group’ Category
The EOC mentions the lack of reproducibility of the gene-editing technique, known as NgAgo. Alongside it, the journal has published a correspondence which includes data from three separate research groups that cast doubt on the original findings.
According to a spokesperson for the journal, some of the paper’s authors have objected to the decision to issue an EOC.
Earlier this month, we reported on a letter signed by 20 researchers which also raised concerns about the genome-editing activities of NgAgo — and alleged the lab that produced the initial results turned away investigators when they attempted to validate the tool in mammalian cells.
Last week, we learned a 2016 paper heavily discussed on PubPeer might be retracted — today, we learned that Nature Cell Biology has indeed pulled the paper, citing inappropriate image modifications.
As we reported last week, a comment on PubPeer flagged as coming from an author said they had requested a retraction. A representative of National Taiwan University (NTU) told us the first author had resigned, and the paper was under investigation — an investigation which included the last author, a prominent researcher who is also a vice president at another institution in Taiwan.
A new letter signed by 20 researchers is casting additional doubts on the validity of a potentially invaluable lab tool — and alleges the lab that produced the initial results turned them away when they tried to replicate its findings in mammalian cells.
In a letter published this week in Protein & Cell, the researchers add their voices to the critics of the gene-editing technique, first described earlier this year in Nature Biotechnology.
The researchers outline their attempts to apply the technique — known as NgAgo — to a variety of cell types, which fell short:
A Nature Cell Biology paper published only a few months ago by prominent researchers in Taiwan has sparked a heated discussion on PubPeer, which now includes a comment allegedly from an author saying they have requested its retraction.
Although a representative of the journal wouldn’t confirm to us that the authors had requested a retraction, the comment on PubPeer says the paper contains several figures that were “inappropriately manipulated” by the first author.
Here’s the full comment on PubPeer, tagged as coming from one of the authors of the paper:
Nature Communications has issued an expression of concern for a 2014 paper by beleaguered surgeon Paolo Macchiarini, citing concerns over whether the paper accurately reports the experiments that were carried out.
According to the notice, Macchiarini, a former rising star in the field of transplant medicine, agrees with the expression of concern. Three of his 22 co-authors have objected.
“Experimental orthotopic transplantation of a tissue-engineered oesophagus in rats” describes transplanting an esophagus into rats that was seeded with their own stem cells, and notes that all animals survived the study period (14 days), and gained more weight than rats given a placebo operation. It’s a topic Macchiarini has made famous, as the first surgeon to perform a similar procedure with a human tracheal transplant. But he’s faced charges of misconduct in the last few years, resulting in his dismissal from Karolinska Institutet (KI).
A cancer biologist has retracted a 2016 News & Views article in a Nature journal, alleging that the journal tried to censor his writing by asking him to remove passages that criticized another journal (Cell).
Carlo Croce, the sole author of the article in Nature Reviews Clinical Oncology from Ohio State University in Columbus, described the journal’s actions to us as “disgusting” and “worrisome.”
A spokesperson from the journal sent us this statement:
We regret that this situation occurred. We cannot comment beyond the retraction notice.
This isn’t Croce’s first retraction (we just found another recent one, in the Journal of Biological Chemistry, over image problems). He’s also co-authored multiple papers with Alfredo Fusco, a cancer researcher in Italy who has nine retractions under his belt, and is undergoing criminal investigation for scientific misconduct.
Here’s the retraction notice, published in Nature Reviews Clinical Oncology on October 4: Read the rest of this entry »
A second paper about a major randomized trial in Japanese patients with heart disease is being retracted, after an investigation reportedly found multiple problems with the paper.
As predicted by Pharma Japan, Hypertension Research is retracting a 2011 paper, already the subject of two errata. Although a spokesperson said she couldn’t say why the paper was being retracted, as the notice was still in production, editor Toshihiko Ishimitsu told us: Read the rest of this entry »
In December 2015, an ORI probe into the work of Girija Dasmahapatra concluded that he had
…duplicated, reused, and/or relabeled Western blot panels and mouse images and claimed they represented different controls and/or experimental results…
Dasmahapatra left the Virginia Commonwealth University (VCU) in July 2015.
After a prominent researcher was dismissed due to multiple instances of misconduct in his studies, how are journals responding?
When an investigation by the U.S. Food and Drug Administration (FDA) found multiple issues with the work of psychiatry researcher Alexander Neumeister, New York University (NYU) Langone Medical Center shut down eight of his studies. (Disclosure: The author of this post is an NYU journalism student, but has no relationship with the medical school.) The agency concluded the studies, which involved using experimental drugs to relieve symptoms of post-traumatic stress disorder (PTSD), were tainted by lax oversight, falsified records, and inaccurate case histories, according to the New York Times. (Neuroskeptic also recently analyzed the case.)
We reached out to the journals that have published Neumeister’s papers, to ask if these recent events have caused them to take a second look at his work. Several have responded, with some noting they plan to investigate, or will do so if asked by the institution. But many believe there is little cause for concern. Read the rest of this entry »
We first came across on the now-retracted paper in the International Journal of Obesity (IJO) in April when we reported on the authors’ other retraction in Diabetes. The 2014 paper had a corrigendum, published the same year, and also for image-related issues. Since then, however, the journal has pulled the IJO paper and its associated corrigendum at the request of the French National Institute of Agronomic Research (INRA) in Paris. Read the rest of this entry »