Retraction Watch

Tracking retractions as a window into the scientific process

Archive for the ‘pnas’ Category

Genotyping mistake costs lab two papers and year of work

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PNASResearchers are retracting two papers about molecular signalling in plants — including one from the Proceedings of the National Academy of Sciences (PNAS) — after discovering some inadvertent genotyping errors. But that was only after they used the problematic plants for an entire year without realizing they’d made a mistake.

In a pair of refreshingly transparent and detailed notices, the authors explain that the transgenic plants used in the papers included genotyping errors, which invalidated their findings. According to the notices, first author Man-Ho Oh generated the problematic transgenic plants, while corresponding author Steven C. Huber, based at University of Illinois, Urbana-Champaign (UIUC), took responsibility for omitting some critical oversight.

Huber told us that there were only two papers that used the transgenic plants in question, so no other retractions will be forthcoming.

Here’s the notice in PNAS for “Autophosphorylation of Tyr-610 in the receptor kinase BAK1 plays a role in brassinosteroid signaling and basal defense gene expression:”  Read the rest of this entry »

Authors retract PNAS paper suggesting silk stabilizes vaccines

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PNASA PNAS paper that caught the media’s attention for suggesting that adding silk could stabilize vaccines and antibiotics has been pulled after the authors realized there were significant errors in the data analysis. 

According to the notice, the authors agreed to retract the 2012 paper; however, the corresponding author told us the authors did not think a retraction was required as, according to him, the conclusions remained valid.

The paper presented a solution to the long-standing problem that sensitive biological compounds such as vaccines and antibiotics begin to lose their effectiveness outside the recommended temperature range, and naturally biodegrade over time. The degradation process cannot be reversed, and may even speed up during transport or storage under less ideal temperatures.

Here’s the retraction notice: Read the rest of this entry »

Context matters when replicating experiments, argues study

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PNASBackground factors such as culture, location, population, or time of day affect the success rates of replication experiments, a new study suggests.

The study, published today in the Proceedings of the National Academy of Sciences, used data from the psychology replication project, which found only 39 out of 100 experiments live up to their original claims. The authors conclude that more “contextually sensitive” papers — those whose background factors are more likely to affect their replicability — are slightly less likely to be reproduced successfully.

They summarize their results in the paper:

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Written by Dalmeet Singh Chawla

May 23rd, 2016 at 3:00 pm

Shigeaki Kato up to 38 retractions

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Shigeaki Kato

Shigeaki Kato

Our retraction notice count for Shigeaki Kato, number seven on our leaderboard, has grown to 38.

The former University of Tokyo endocrinologist recently earned another retraction, for a paper in Archives of Biochemistry and Biophysics that contained image manipulation. As we’ve noted before, Kato resigned from the university in 2012 as it investigated his work for misconduct; in 2013 a Japanese newspaper reported that the investigation had found 43 papers from his lab contained “likely altered or forged materials.”

In addition to the new retraction, we’ve dug up four others for Kato from the past few years, plus one correction. Two of the retraction notices mention an investigation at the University of Tokyo.

First, the retraction note for “Multiple co-activator complexes support ligand-induced transactivation function of VDR,” published in December:

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Fast-tracked PNAS papers are cited less often — but gap is shrinking

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PNASAn analysis of more than 50,000 papers submitted to Proceedings of the National Academy of Sciences (PNAS) shows that those published using its “contributed track” — in which academy members can fast-track their own papers by coordinating the peer-review process themselves — have been cited less often than regular submissions, but that gap is shrinking.

Although the overall average difference in citations between contributed and regular submissions was 9%, the yearly difference has declined from 13.6% in 2005 to 2.2% in 2014, according to the new study, posted before peer review on the preprint server bioRxiv by Phil Davis, an independent researcher and publishing consultant based in New York.

The contributed track is a long-standing editorial practice of PNAS, which has triggered concerns from some academics that say Read the rest of this entry »

Written by Dalmeet Singh Chawla

January 15th, 2016 at 12:45 pm

Five years after a retraction, company’s stock is up more than 500%

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wntloggawntresearchwebny1Is ethical behavior good for business?

Five years ago this month, Swedish pharmaceutical company WntResearch immediately notified shareholders when authors retracted a 2009 Proceedings of the National Academy of Sciences (PNAS) paper on a potential cancer therapy that was key to the company’s business.

At the time, the company’s decision to disclose the retraction hurt its finances, as WntResearch delayed its planned initial public offering for three weeks. It also offered investors and shareholders the opportunity to withdraw their shares of WntResearch stock.

But, aside from one of the paper’s co-authors, “No one did that,” Nils Brünner, WntResearch’s CEO, told us. Since the company’s IPO on December 17, 2010, its stock price has increased from Read the rest of this entry »

First author refuses to sign PNAS retraction after “key findings” are not reproduced

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Two out of the three authors of a PNAS paper on mutations underlying lung diseases are pulling it after failing to reproduce key findings.

The paper, published in 2012, investigated how mutations in lung surfactant genes induce molecular changes that lead to lung pulmonary fibrosis and lung cancer might work. But follow-up work revealed problems. In the retraction note, last author Christine Kim Garcia and second author Christoper Cano, both at the University of Texas Southwestern Medical Center, write:

Current members of the C.K.G. laboratory are unable to reproduce key findings reported in the paper.

Here’s the retraction note in full:

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Voinnet notches second retraction, two more corrections

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PNASOlivier Voinnet — a plant researcher who was recently suspended for two years from the Centre national de la recherche scientifique (CNRS) after an investigation by ETH Zurich and CNRS found evidence of misconduct — has issued his second retraction and two more corrections.

PNAS posted the retraction earlier this week for a 2006 article after an inspection of the raw data revealed “errors” in study images. Authors confirmed the issues in some figures and revealed “additional mounting mistakes” in others.

Voinnet has promised to issue retractions and corrections for every study that requires them. These latest notices bring our tally up to nine corrections, two retractions and one Expression of Concern.

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PNAS paper on dengue virus pulled due to contamination

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PNAS_ak11smThe authors of a paper on dengue virus vaccine design published last year in PNAS are retracting it after discovering that their experimental dengue virus was contaminated.

Although they are confident that the strategy is sound, the authors write in their commendably detailed retraction notice that the “inadvertent error” rendered the results “uninterpretable.”

Here’s the retraction notice: Read the rest of this entry »

Written by Alla Katsnelson

May 12th, 2015 at 9:30 am

Second paper for Duke lung researchers expires in a retraction

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pnas 3 5 13Scientists at Duke and the National Institutes of Health have retracted a PNAS paper on asthma treatment after realizing the data from two sources didn’t match, and “most primary data” from several experiments were missing.

The mix up seems to have come from the pulmonary function laboratory that tested how well asthmatic patients’ lungs were functioning on an experimental anti-inflammatory therapy. As the authors say in the retraction note: Read the rest of this entry »

Written by Cat Ferguson

April 6th, 2015 at 11:30 am