Retraction Watch

Tracking retractions as a window into the scientific process

Archive for the ‘carcinogenesis’ Category

Duplicated data, “careless errors” expire lung cancer paper

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A paper about the molecular details of lung cancer is being retracted for repeating datasets and “careless errors” in a pair of figures.

According to the note, the editor of Carcinogenesis wouldn’t have known about the problems if he hadn’t been tipped off that the paper by first author, XiaoJuan Sun — a researcher at Shenzhen Second People’s Hospital in China — shared “significant similarities” with another one of Sun’s papers that was retracted years ago. After the journal investigated the paper, it discovered that the authors had reported the same data as in the retracted paper “without significant additions or amendments,” along with some errors and inconsistencies.

Here’s the detailed note for “The EDA-containing cellular fibronectin induces epithelial mesenchymal transition in lung cancer cells through integrin α9β1-mediated activation of PI3-K /Akt and Erk1/2:”

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Journal takes different tacks on two cancer papers with image problems

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carcinogenCarcinogenesis has the publishing world’s version of a twin problem: two dysfunctional articles yet one gets retracted while the other merely suffers a correction. Is it nature — or nurture?

Here are the details. One article, “Chemopreventive effect of dietary glutamine on colitis-associated colon tumorigenesis in mice,” came from a group in China. Published earlier this year, the authors seem to have had some trouble with their figures. As the corrigendum explains:  Read the rest of this entry »

Written by amarcus41

December 12th, 2013 at 11:30 am

Environmental scientists call for retraction of oil industry-funded paper on benzene exposure

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carcinogenesis 13A paper suggesting that scientists may want to rethink what levels of benzene are carcinogenic has led to a sharp exchange in the journal that originally published it.

In 2006, Stephen Rappaport, of UNC-Chapel Hill, and colleagues, published a paper that began by saying that benzene

is an important industrial chemical that is also emitted into the air from gasoline, engine exhausts and combustion of organic materials (including cigarette smoke) (1,2). Occupational exposures to benzene at air levels greater than ∼10 p.p.m., have long been linked to hematotoxicity and to acute myelogenous leukemia (35). A recent report of hematotoxic effects in workers exposed to benzene <1 p.p.m. (6) has raised additional concerns regarding the health consequences of low exposures to this contaminant.

The authors conclude: Read the rest of this entry »

Written by Ivan Oransky

April 8th, 2013 at 9:30 am

Authors retract prostate cancer-grape seed compound paper for figure presentation error

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University of Alabama researchers have retracted a paper claiming that a grape skin seed compound might have anti-prostate cancer effects.

Here’s the notice for “Proanthocyanidins from grape seeds inhibit expression of matrix metalloproteinases in human prostate carcinoma cells, which is associated with the inhibition of activation of MAPK and NFκB”: Read the rest of this entry »