Sometimes, apparently, a retraction isn’t enough to put research findings to bed forever. Consider this obituary recently posted online at the Journal of Pediatrics, for a method of detecting gastroesophageal reflux disease (GERD) in children:
We commonly recognize the contributions of distinguished members of the pediatric community and, with regret, their passing. It is appropriate, therefore, that we acknowledge the timely death of an old friend, the pH probe. Crushed to death under the weight of evidence against it, it was found abandoned in a trash can with a note that read, ‘‘Good riddance to a bad test.’’
To be fair, the pH probe has always been the standard bearer for mediocrity.
A Cell paper reporting on genetic mutations responsible for a form of muscular dystrophy was retracted earlier this month. According to the retraction:
Our paper reported the identification of mutations in the gene VMA21 in patients with X-linked myopathy with excessive autophagy (XMEA) and characterized the molecular mechanisms underlying the disease phenotype. Many of the figure panels in the paper summarize data from multiple experiments. We have now detected a number of errors in these panels. Although we stand by the validity of our conclusions, we believe that the most responsible course of action is to retract our paper. We are preparing an expanded version of our work for future submission. We deeply regret this circumstance and apologize to the community.
One of the original authors, Dr. Aubourg, could not be reached regarding this Retraction.
The study has been cited 11 times, according to Thomson Scientific’s Web of Knowledge. Here’s a press release the researchers’ hospital, Sick Kid’s of Toronto, sent out when it was originally published.
Well, it’s happened: The Embargo Watch and Retraction Watch worlds have collided. I had initially figured on two posts here, but it soon became clear that how journals were handling these retractions, using embargoes, was central to both. So this is being cross-posted on both blogs.
Linda Buck, who shared the 2004 Nobel Prize in Physiology or Medicine, has retracted two papers published in 2005 and 2006. Both retractions — one in the Proceedings of the National Academy of Sciences (PNAS) and one in Science — appear online today.
The papers describe how nerves that carry information about scents connect from the nose to the olfactory bulb, where they are processed. They were published after the 2004 Nobel, which was for discoveries “of odorant receptors and the organization of the olfactory system.”
Harvard Medical School has formed an ad hoc committee to review the retraction, and Buck has asked the Fred Hutchinson Cancer Research Center to review two later publications on which Zou was the lead author. “It’s disappointing of course,” says Buck. “The important thing is to correct the literature.”
The PNAS and Science retractions are of those two later publications. The PNAS study was cited 61 times, and the Science study was cited 73 times, according to the Thomson Scientific Web of Knowledge.
Over the summer, while searching for some studies and evidence for various treatments, my wife, a television writer and producer, noticed something she thought unusual enough to flag for me. The titles of a number of Cochrane Library reviews started with “WITHDRAWN.”
The Cochrane Library is the world’s leading publisher of systematic reviews, which gather all of the high-quality evidence on a given subject and offer a rigorous analysis of whether a given test or treatment works. It’s an invaluable resource. (Shameless plug: Join the Association of Health Care Journalists, where I’m treasurer, and access to the $285-per-year Cochrane subscription is included.)
Retraction Watch was curious about what “WITHDRAWN” meant, since “withdrawal” is often used synonymously with retraction. Cochrane updates its reviews regularly, as new evidence surfaces, of course. But these abstracts didn’t say anything about new reviews.
Last month, we wrote about the retraction of a 2005 paper suggesting that some adult stem cells might give rise to cancer. That, of course, would be a problem if researchers tried treating heart disease and other conditions with them. The paper’s authors retracted it, however, when it became clear that instead of being transformed — that’s the scientific word for “became cancerous” — the cells had simply become contaminated and overgrown with tumor cells used in research.
The authors of a 2005 Cancer Research paper that cast some doubt on the safety of a population of adult stem cells used frequently in research have retracted it. According to the retraction, in the August 15 issue of the journal:
Upon review of the data published in this article, the authors have been unable to reproduce some of the reported spontaneous transformation events and suspect the phenomenon is due to a cross-contamination artifact.
It takes decades, and even centuries, to overturn the Catholic canon of law, but medical journals move much more quickly: Just three weeks after the Virology Journal published a paper speculating that a woman described in the Bible as being “cured by our Lord Jesus Christ” had flu, the journal has apologized for ever posting it online.