Retraction Watch

Tracking retractions as a window into the scientific process

Cancer researcher earns 9th retraction, for image duplication

with 64 comments

Journal of Clinical InvestigationAlfredo Fusco, a researcher in Italy who has been under criminal investigation for scientific misconduct, has earned his ninth retraction.

Retraction number nine, by The Journal of Clinical Investigation, is for duplicating data from another publication — which has also faced questions on PubPeer about image manipulation, along with many other papers by Fusco.

The retraction note for “The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells” explains that the journal is pulling the paper even though the authors claim that they can reproduce the data:

At the request of the corresponding author, the JCI is retracting this manuscript. The corresponding author recently notified the JCI that multiple microscopy images in Figure 2B were previously published and were used to represent different samples in another publication by the corresponding author’s group (1). The authors have stated that experimental data produced ad hoc are consistent with those in the original publication; however, the paper is being retracted due to data duplication and misrepresentation in the original publication.

The 2005 paper has been cited 226 times, according to Thomson Reuters Web of Science.

That paper cited in the note, “The Oncogenic Activity of RET Point Mutants for Follicular Thyroid Cells May Account for the Occurrence of Papillary Thyroid Carcinoma in Patients Affected by Familial Medullary Thyroid Carcinoma,” was published in 2004 by The American Journal of Pathology. On PubPeer, commenters suggested that another figure in that paper resembles one from a previously published paper co-authored by Fusco, and some parts of a figure appear to be duplicated within the paper itself.

Fusco is an author on both papers, which share a few authors including the first and last authors: Rosa Marina Melillo and Massimo Santoro, both affiliated with the University of Naples. Fusco is also listed at the University of Naples. We’ve reached out to Fusco, Santoro (the corresponding author) and to the university for more information.

We’ve also contacted the editor of The American Journal of Pathology to see if the journal has looked into the paper mentioned in the retraction note.

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Comments
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    1Department of Experimental and Clinical Medicine, Medical School of Catanzaro, ‘Magna Graecia’ University of Catanzaro, 88100 Catanzaro, Italy.

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    1Dipartimento di Biologia e Patologia Cellulare e Molecolare, Centro di Endocrinologia ed Oncologia Sperimentale del CNR, Facoltà di Medicina e Chirurgia di Napoli, Federico II Università degli Studi di Napoli, via Pansini 5, 80131 Naples, Italy.

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    1Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli Federico II, 80131 Naples, Italy.

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    1Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Dipartimento di Patologia Cellulare e Molecolare, Università degli Studi di Napoli Federico II, via Pansini 5, 80131 Naples, Italy.

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    1Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Dipartimento di Biologiae Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli, Italy.

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    1Centro di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia, Università di Napoli Federico II, Naples, Italy.

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    1Dipartimento di Biologia e Patologia Cellulare e Molecolare, c/o Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli Federico II, via Pansini, 5, 80131 Naples, Italy.

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    1Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli ‘Federico II’, Naples, Italy.

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    • fernandopessoa July 11, 2016 at 10:14 am

      Figure 1a has been replaced in a 2016 correction.

      http://www.nature.com/onc/journal/vaop/ncurrent/full/onc2016139a.html

      The authors wish to replace Figure 1a with the following figure, which shows an alternative experiment. Representative ATC (anaplastic thyroid carcinoma) (n=6) and PTC (papillary thyroid carcinoma) (n=6). samples were analyzed for the expression of the miR-30d, miR-125b, miR-26a, miR30a-5p. As control, three normal thyroid samples were used. The results confirm the strong downregulation of the examined miRs in ATC but not in PTC samples. For this experiment, qRT-PCR analysis was performed in 6 papillary (PTC1-6) and 6 anaplastic (ATC1-6) thyroid carcinoma samples. cDNAs were generated by using miScript Kit (Qiagen, Valencia, CA, USA), and amplifications were performed by using miScript SYBR Green PCR Kit (Qiagen) and miScript Primer Assays for miR-30d, miR-125b, miR-26a, miR30a-5p and U6 for normalization (Qiagen). Reactions were performed in duplicate in a real-time CFX96 thermocycler (Bio-Rad, Hercules, CA, USA). The relative quantity of each microRNA was normalized to the U6 RNA amount by using the 2-DDCt formula and the values indicate relative expression levels in tumor samples±s.d. compared with average expression levels of three normal thyroid samples.

  • fernandopessoa April 6, 2016 at 10:03 am

    Endocr Relat Cancer. 2009 Jun;16(2):483-90. doi: 10.1677/ERC-08-0272. Epub 2009 Mar 4.
    Impairment of the p27kip1 function enhances thyroid carcinogenesis in TRK-T1 transgenic mice.
    Fedele M1, Palmieri D, Chiappetta G, Pasquinelli R, De Martino I, Arra C, Palma G, Valentino T, Pierantoni GM, Viglietto G, Rothstein JL, Santoro M, Fusco A.
    Author information
    1Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, 80131 Naples, Italy.

    https://pubpeer.com/publications/19261681

    http://i.imgur.com/BiCgD6T.jpg

  • fernandopessoa April 6, 2016 at 10:12 am

    Oncogene. 2010 Jul 29;29(30):4341-51. doi: 10.1038/onc.2010.179. Epub 2010 May 24.
    CCDC6 represses CREB1 activity by recruiting histone deacetylase 1 and protein phosphatase 1.
    Leone V1, Mansueto G, Pierantoni GM, Tornincasa M, Merolla F, Cerrato A, Santoro M, Grieco M, Scaloni A, Celetti A, Fusco A.
    Author information
    1Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli Federico II, Naples, Italy.

    https://pubpeer.com/publications/20498639

    http://i.imgur.com/7BMsNWC.jpg

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  • fernandopessoa April 6, 2016 at 10:22 am

    Mol Endocrinol. 2011 Oct;25(10):1819-30. doi: 10.1210/me.2011-0014. Epub 2011 Aug 4.
    A TSH-CREB1-microRNA loop is required for thyroid cell growth.
    Leone V1, D’Angelo D, Ferraro A, Pallante P, Rubio I, Santoro M, Croce CM, Fusco A.
    Author information
    1Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli Federico II, Naples, Italy.

    https://pubpeer.com/publications/21816899

    http://i.imgur.com/xJiisYH.jpg

  • fernandopessoa April 6, 2016 at 10:53 am

    J Pathol. 2011 May;224(1):110-20. doi: 10.1002/path.2846. Epub 2011 Mar 7.
    Down-regulation of oestrogen receptor-β associates with transcriptional co-regulator PATZ1 delocalization in human testicular seminomas.
    Esposito F1, Boscia F, Franco R, Tornincasa M, Fusco A, Kitazawa S, Looijenga LH, Chieffi P.
    Author information
    1Dipartimento di Medicina Sperimentale, II Università di Napoli, Naples, Italy.

    https://pubpeer.com/publications/13955DF2DEE158B7C685A5468CBB93

    http://i.imgur.com/yizNzbM.jpg

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  • fernandopessoa April 6, 2016 at 10:56 am

    J Clin Endocrinol Metab. 2012 Jul;97(7):E1128-38. doi: 10.1210/jc.2011-3482. Epub 2012 May 7.
    Altered microRNA expression profile in human pituitary GH adenomas: down-regulation of miRNA targeting HMGA1, HMGA2, and E2F1.
    D’Angelo D1, Palmieri D, Mussnich P, Roche M, Wierinckx A, Raverot G, Fedele M, Croce CM, Trouillas J, Fusco A.
    Author information
    1Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche (CNR) c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita` degli Studi di Napoli, Napoli, Italy.

    https://pubpeer.com/publications/22564666

    http://i.imgur.com/59g6fAe.jpg

  • fernandopessoa April 6, 2016 at 10:59 am

    Mol Oncol. 2013 Jun;7(3):531-42. doi: 10.1016/j.molonc.2013.01.002. Epub 2013 Jan 17.
    The High Mobility Group A proteins contribute to thyroid cell transformation by regulating miR-603 and miR-10b expression.
    Mussnich P1, D’Angelo D, Leone V, Croce CM, Fusco A.
    Author information
    1Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli Federico II, Naples, Italy.

    https://pubpeer.com/publications/23384558

    http://i.imgur.com/ZyyhpTE.jpg

  • fernandopessoa April 6, 2016 at 11:01 am

    BMC Cancer. 2013 Sep 24;13:433. doi: 10.1186/1471-2407-13-433.
    Critical role of CCDC6 in the neoplastic growth of testicular germ cell tumors.
    Staibano S1, Ilardi G, Leone V, Luise C, Merolla F, Esposito F, Morra F, Siano M, Franco R, Fusco A, Chieffi P, Celetti A.
    Author information
    1Istituto di Endocrinologia ed Oncologia Sperimentale, CNRz, via S Pansini, 5, Naples 80131, Italy.

    https://pubpeer.com/publications/24059746

    http://i.imgur.com/DHNutrW.jpg

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  • fernandopessoa April 6, 2016 at 11:04 am

    Cancer Res. 2010 Jul 1;70(13):5379-88. doi: 10.1158/0008-5472.CAN-09-4199. Epub 2010 Jun 8.
    High-mobility group A1 proteins regulate p53-mediated transcription of Bcl-2 gene.
    Esposito F1, Tornincasa M, Chieffi P, De Martino I, Pierantoni GM, Fusco A.
    Author information
    1Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Università degli Studi di Napoli Federico II, Naples, Italy.

    https://pubpeer.com/publications/20530667

    http://i.imgur.com/1Kzj90r.jpg

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    BMC Biol. 2009 May 21;7:24. doi: 10.1186/1741-7007-7-24.
    The cAMP-HMGA1-RBP4 system: a novel biochemical pathway for modulating glucose homeostasis.
    Chiefari E1, Paonessa F, Iiritano S, Le Pera I, Palmieri D, Brunetti G, Lupo A, Colantuoni V, Foti D, Gulletta E, De Sarro G, Fusco A, Brunetti A.
    Author information
    1Dipartimento di Medicina Sperimentale e Clinica G. Salvatore, Catanzaro, Italy.

    http://i.imgur.com/oCC6gSF.jpg

  • fernandopessoa April 6, 2016 at 11:15 am

    Cancer Res. 2009 Mar 1;69(5):1844-50. doi: 10.1158/0008-5472.CAN-08-4133. Epub 2009 Feb 17.
    HMGA proteins up-regulate CCNB2 gene in mouse and human pituitary adenomas.
    De Martino I1, Visone R, Wierinckx A, Palmieri D, Ferraro A, Cappabianca P, Chiappetta G, Forzati F, Lombardi G, Colao A, Trouillas J, Fedele M, Fusco A.
    Author information
    1Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, Italy.

    https://pubpeer.com/publications/19223528

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  • fernandopessoa April 6, 2016 at 11:18 am

    J Pathol. 2008 May;215(1):39-47. doi: 10.1002/path.2323.
    PATZ1 gene has a critical role in the spermatogenesis and testicular tumours.
    Fedele M1, Franco R, Salvatore G, Paronetto MP, Barbagallo F, Pero R, Chiariotti L, Sette C, Tramontano D, Chieffi G, Fusco A, Chieffi P.
    Author information
    1IEOS, CNR and Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli ‘Federico II, 80131 Naples, Italy.

    https://pubpeer.com/publications/18241078

    http://i.imgur.com/wKB8ehB.jpg

  • fernandopessoa April 6, 2016 at 11:21 am

    Endocr Relat Cancer. 2007 Jun;14(2):405-20.
    Overexpression of the S-phase kinase-associated protein 2 in thyroid cancer.
    Chiappetta G1, De Marco C, Quintiero A, Califano D, Gherardi S, Malanga D, Scrima M, Montero-Conde C, Cito L, Monaco M, Motti ML, Pasquinelli R, Agosti V, Robledo M, Fusco A, Viglietto G.
    Author information
    1Laboratorio Oncologia Sperimentale III, Istituto Nazionale Tumori, via M. Semmola, 80131 Napoli, Italy.

    https://pubpeer.com/publications/17639054
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  • fernandopessoa April 6, 2016 at 11:23 am

    Endocr Relat Cancer. 2007 Sep;14(3):875-86.
    The Mia/Cd-rap gene expression is downregulated by the high-mobility group A proteins in mouse pituitary adenomas.
    De Martino I1, Visone R, Palmieri D, Cappabianca P, Chieffi P, Forzati F, Barbieri A, Kruhoffer M, Lombardi G, Fusco A, Fedele M.
    Author information
    1Dipartimento di Biologia e Patologia Cellulare e Molecolare and Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, University of Naples Federico II, via Pansini 5, 80131 Naples, Italy.

    https://pubpeer.com/publications/17914116

    http://i.imgur.com/cu6OTUO.jpg

  • fernandopessoa April 6, 2016 at 11:25 am

    Oncogene. 2007 Sep 13;26(42):6167-75. Epub 2007 Apr 9.
    Involvement of H4(D10S170) protein in ATM-dependent response to DNA damage.
    Merolla F1, Pentimalli F, Pacelli R, Vecchio G, Fusco A, Grieco M, Celetti A.
    Author information
    1Dipartimento di Biologia e Patologia Cellulare e Molecolare, University ‘Federico II’, Naples, Italy.

    http://i.imgur.com/klwrqFk.jpg

    http://i.imgur.com/yzyLi18.jpg

  • fernandopessoa April 6, 2016 at 11:28 am

    PLoS Genet. 2007 Jul;3(7):e110.
    DNA damage, homology-directed repair, and DNA methylation.
    Cuozzo C1, Porcellini A, Angrisano T, Morano A, Lee B, Di Pardo A, Messina S, Iuliano R, Fusco A, Santillo MR, Muller MT, Chiariotti L, Gottesman ME, Avvedimento EV.
    Author information
    1Dipartimento di Biologia e Patologia Molecolare e Cellulare, Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Università Federico II, Naples, Italy.

    https://pubpeer.com/publications/17616978

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  • fernandopessoa April 6, 2016 at 12:16 pm

    Mol Endocrinol. 2007 Jan;21(1):229-46. Epub 2006 Oct 4.
    An intracellular multi-effector complex mediates somatostatin receptor 1 activation of phospho-tyrosine phosphatase eta.
    Arena S1, Pattarozzi A, Massa A, Esteve JP, Iuliano R, Fusco A, Susini C, Florio T.
    Author information
    1Section of Pharmacology, Department of Oncology, Biology and Genetics, Univertsity of Genova 16132 Genova, Italy.

    https://pubpeer.com/publications/17021051

    http://i.imgur.com/XHXvdBQ.jpg

  • fernandopessoa April 6, 2016 at 12:19 pm

    Cancer Res. 2006 Mar 1;66(5):2536-43.
    Haploinsufficiency of the Hmga1 gene causes cardiac hypertrophy and myelo-lymphoproliferative disorders in mice.
    Fedele M1, Fidanza V, Battista S, Pentimalli F, Klein-Szanto AJ, Visone R, De Martino I, Curcio A, Morisco C, Del Vecchio L, Baldassarre G, Arra C, Viglietto G, Indolfi C, Croce CM, Fusco A.
    Author information
    1Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli Federico II, Italy.

    https://pubpeer.com/publications/16510570

    http://i.imgur.com/Oig5qCF.jpg

    http://i.imgur.com/mtDwmgD.jpg

  • fernandopessoa April 6, 2016 at 12:20 pm

    Cell Div. 2006 Aug 17;1:17.
    E2F1 activation is responsible for pituitary adenomas induced by HMGA2 gene overexpression.
    Fedele M1, Pierantoni GM, Visone R, Fusco A.
    Author information
    1Istituto di Endocrinologia e Oncologia Sperimentale del CNR e Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli Federico II, via S, Pansini, 5 80131 Napoli, Italy.

    https://pubpeer.com/publications/16914062

    http://i.imgur.com/fFLbri1.jpg

  • fernandopessoa April 6, 2016 at 12:22 pm

    Oncogene. 2005 Oct 13;24(45):6809-19.
    HMGA1 protein expression sensitizes cells to cisplatin-induced cell death.
    Baldassarre G1, Belletti B, Battista S, Nicoloso MS, Pentimalli F, Fedele M, Croce CM, Fusco A.
    Author information
    1Kimmel Cancer Center, Jefferson Medical College, Philadelphia, PA 19107, USA.

    https://pubpeer.com/publications/16007157

    http://i.imgur.com/w6IpISi.jpg

  • fernandopessoa April 6, 2016 at 12:26 pm

    Cancer Res. 2004 Aug 15;64(16):5728-35.
    Identification of the genes up- and down-regulated by the high mobility group A1 (HMGA1) proteins: tissue specificity of the HMGA1-dependent gene regulation.
    Martinez Hoyos J1, Fedele M, Battista S, Pentimalli F, Kruhoffer M, Arra C, Orntoft TF, Croce CM, Fusco A.
    Author information
    1Dipartimento di Biologia e Patologia Cellulare e Molecolare e/o Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli “Federico II,” Naples, Italy.

    https://pubpeer.com/publications/15313913

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  • fernandopessoa April 6, 2016 at 12:28 pm

    FASEB J. 2003 Aug;17(11):1496-8. Epub 2003 Jun 17.
    Loss of Hmga1 gene function affects embryonic stem cell lympho-hematopoietic differentiation.
    Battista S1, Pentimalli F, Baldassarre G, Fedele M, Fidanza V, Croce CM, Fusco A.
    Author information
    1Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o Centro di Endocrinologia ed Oncologia Sperimentale del CNR, Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli Federico II, via Pansini 5, 80131 Naples, Italy.

    https://pubpeer.com/publications/12824305

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  • fernandopessoa April 6, 2016 at 12:30 pm

    Biochem J. 2003 May 15;372(Pt 1):145-50.
    High-mobility group A1 proteins are overexpressed in human leukaemias.
    Pierantoni GM1, Agosti V, Fedele M, Bond H, Caliendo I, Chiappetta G, Lo Coco F, Pane F, Turco MC, Morrone G, Venuta S, Fusco A.
    Author information
    1Department of Biology and Molecular/Cellular Pathology, c/o CNR Center for Endocrinology and Experimental Oncology, Faculty of Medicine and Surgery, Federico II University of Naples, via S. Pansini 5, 80131 Naples, Italy.

    https://pubpeer.com/publications/12573034

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  • fernandopessoa April 6, 2016 at 12:32 pm

    Mol Cell Biol. 2003 Apr;23(7):2225-38.
    Negative regulation of BRCA1 gene expression by HMGA1 proteins accounts for the reduced BRCA1 protein levels in sporadic breast carcinoma.
    Baldassarre G1, Battista S, Belletti B, Thakur S, Pentimalli F, Trapasso F, Fedele M, Pierantoni G, Croce CM, Fusco A.
    Author information
    1Kimmel Cancer Center, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA.

    https://pubpeer.com/publications/12640109

    http://i.imgur.com/UtU1PJJ.jpg

  • fernandopessoa April 6, 2016 at 12:37 pm

    Thyroid. 2002 Sep;12(9):765-72.
    Thymosin beta-10 protein synthesis suppression reduces the growth of human thyroid carcinoma cells in semisolid medium.
    Santelli G1, Bartoli PC, Giuliano A, Porcellini A, Mineo A, Barone MV, Busiello I, Trapasso F, Califano D, Fusco A.
    Author information
    1Oncologia Sperimentale E, Istituto Nazionale dei Tumori di Napoli, Fondazione G. Pascale, Napoli, Italy.

    https://pubpeer.com/publications/12481941

    http://i.imgur.com/LO360S9.jpg

  • fernandopessoa April 6, 2016 at 12:39 pm

    J Biol Chem. 2002 Feb 1;277(5):3280-5. Epub 2001 Nov 21.
    PATZ attenuates the RNF4-mediated enhancement of androgen receptor-dependent transcription.
    Pero R1, Lembo F, Palmieri EA, Vitiello C, Fedele M, Fusco A, Bruni CB, Chiariotti L.
    Author information
    1Centro di Endocrinologia ed Oncologia Sperimentale del CNR “G. Salvatore,” Dipartimento di Biologia e Patologia Cellulare e Molecolare, “L. Califano” Università degli Studi di Napoli “Federico II,” via S. Pansini, 5, 80131 Napoli, Italy.

    https://pubpeer.com/publications/11719514

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  • fernandopessoa April 6, 2016 at 12:42 pm

    J Biol Chem. 2012 May 25;287(22):18308-17. doi: 10.1074/jbc.M112.346270. Epub 2012 Apr 9.
    POZ-, AT-hook-, and zinc finger-containing protein (PATZ) interacts with human oncogene B cell lymphoma 6 (BCL6) and is required for its negative autoregulation.
    Pero R1, Palmieri D, Angrisano T, Valentino T, Federico A, Franco R, Lembo F, Klein-Szanto AJ, Del Vecchio L, Montanaro D, Keller S, Arra C, Papadopoulou V, Wagner SD, Croce CM, Fusco A, Chiariotti L, Fedele M.
    Author information
    1Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli Federico II and Consiglio Nazionale delle Ricerche (CNR), Naples, Italy.

    http://www.jbc.org/content/289/21/14966.short

    Western blot images representing PATZ, BCL6, and tubulin in Fig. 6C did not accurately represent the experimental results. Different lanes were erroneously duplicated. Lane 3 of the PATZ panel was duplicated in lane 7; lane 4 of the PATZ panel was duplicated in lanes 5 and 6; lane 1 of the BCL6 panel was duplicated in lane 2; lane 4 of the tubulin panel was duplicated in lane 7; and lane 5 of the tubulin panel was duplicated in lane 6. The authors have provided an image from a replicate experiment. This correction does not affect the interpretation or conclusions of this work.

  • fernandopessoa April 6, 2016 at 12:44 pm

    Cell Growth Differ. 2000 Oct;11(10):517-26.
    Retinoic acid induces neuronal differentiation of embryonal carcinoma cells by reducing proteasome-dependent proteolysis of the cyclin-dependent inhibitor p27.
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    Author information
    1Servizio Oncologia Sperimentale E, Istituto Nazionale Tumori, Naples, Italy.

    https://pubpeer.com/publications/11063125

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    J Clin Invest. 1999 Oct;104(7):865-74.
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    Author information
    1Istituto Nazionale dei Tumori “Fondazione Senatore Pascale,” 80131 Naples, Italy.

    https://pubpeer.com/publications/10510327

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  • fernandopessoa April 6, 2016 at 12:50 pm

    Mol Cell Biol. 1987 Sep;7(9):3365-70.
    One- and two-step transformations of rat thyroid epithelial cells by retroviral oncogenes.
    Fusco A1, Berlingieri MT, Di Fiore PP, Portella G, Grieco M, Vecchio G.
    Author information
    1Dipartimento di Biologia e Patologia Cellulare e Molecolare, L. Califano II Facoltà di Medicina e Chirurgia, Università di Napoli, Italy.

    https://pubpeer.com/publications/3670314

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  • fernandopessoa April 6, 2016 at 12:53 pm

    J Virol. 1985 Oct;56(1):284-92.
    A mos oncogene-containing retrovirus, myeloproliferative sarcoma virus, transforms rat thyroid epithelial cells and irreversibly blocks their differentiation pattern.
    Fusco A, Portella G, Di Fiore PP, Berlingieri MT, Di Lauro R, Schneider AB, Vecchio G.

    https://pubpeer.com/publications/2993656

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