Thorax retracts cystic fibrosis paper with bogus data
A group of European researchers is retracting their 2012 paper in Thorax on the link between cystic fibrosis and the common cold after discovering that the first author, a promising young microbiologist in Switzerland, had made up her data.
The article, titled “Impaired type I and type III interferon induction and rhinovirus control in human cystic fibrosis airway epithelial cells,” purported to describe:
a novel mechanism to explain the increased susceptibility of patients with CF to rhinovirus infections. A profound impairment of the antiviral early innate response in CF airway epithelial cells was identified, suggesting a potential use of IFNs in the treatment of rhinovirus-induced CF exacerbations.
The lead author was Marjolaine Vareille, who at the time was at the University of Bern. Vareille won a L’Oréal France grant in 2007 from the Fondation L’Oréal – Unesco-French Academy of Sciences. The paper has been cited eight times, according to Thomson Scientific’s Web of Knowledge.
But according to the retraction notice:
In our article recently published in Thorax, we described a novel mechanism explaining the increased susceptibility of patients with cystic fibrosis (CF) to rhinovirus infections, namely defective interferon type I and III production by CF airway epithelial cells. In experiments performed after publication of the article we were unable to consistently replicate our findings of deficient interferon type I and III production by CF airway epithelial cells upon rhinovirus infection. In the light of these results, we carried out detailed investigations of the data reported in the above manuscript and regrettably found evidence of deliberate manipulation of experimental data by the first author Dr M. Vareille. This manipulation was accompanied in some instances by absence of original data files. The manipulation/original data absence involved data presented in most, if not all of the figures, thus we wish to fully retract the paper and apologise to the readers of Thorax and to the scientific community for the inconvenience this has caused.
We also checked data published by our group in manuscripts on which Dr Vareille was a co-author and found that data published in these manuscripts had not been manipulated. These two manuscripts, whose data and conclusions we stand by are:
Edwards MR, Regamey N, Vareille M, et al. Impaired innate interferon induction in severe therapy resistant atopic asthmatic children. Mucosal Immunol 2013;6:797–806. doi: 10.1038/mi.2012.118.
Kieninger E, Vareille M, Kopf BS, et al. Lack of an exaggerated inflammatory response on virus infection in cystic fibrosis. Eur Respir J 2012;39:297–304. doi: 10.1183/09031936.00054511.
Dr. Vareille has received a letter from the Secretary General of the University of Bern condemning her scientific misconduct as a severe offence against the rules of scientific integrity. Her current employers have also been informed.
All co-authors of the publication including Dr. Vareille concur with the retraction statement.
Hat tip: Harvey Marcovitch