Last week was a busy one at the U.S. Office of Research Integrity (ORI), at least judging by how many cases they posted. There were sanctions against researchers at Ohio State, Texas Tech, and the Gladstone Institutes, as we reported. And it turns out there was another case closed, of a former Harvard dental school research fellow, The Scientist reports.
According to the ORI, Martin Biosse-Duplan “engaged in research misconduct in research supported by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), grant R01 AR054450.”
The misconduct involved a lab presentation and two published abstracts:
- Boisse-Duplan, M., Stephens, S., Lai, F.P.L., Oelkers, M., Kitamura, D., Rottner, K., Horne, W., & Baron, R. “The Association Between the Microtubule Plus End Protein EB1 and Cortactin Controls Podosomes and Bone Resorption.” J Bone Min Res 26:Supl.1, pS215.
- Boisse-Duplan, M., Stephens, S., Lai, F.P.L., Oelkers, M., Rottner, K., Horne, W., & Baron, R. “In Osteoclasts, Dynamic Microtubules and their Associated Protein EB1 Control Podosomes and Bone Resorption through Cortactin.” Bone 48:Suppl. 2, pS97.
According to the ORI:
As a result of HSM’s and HSDM’s investigation, the data were not presented at the meetings and the experiments reported in the abstracts are being redone.
Specifically, ORI finds that Respondent:
Falsified Powerpoint slides and spreadsheets for histomorphometric and microCT results by using the values of HS1 knockout (KO) mice and their controls to represent the CathepsinK cre- Cortactin KO mice and their controls; Dr. Biosse-Duplan also switched two sets of numbers between the HS1 KO mice and their controls to falsely demonstrate a difference in bone density when there was none. The numerical data were presented at a lab meeting, and false text was included in two submitted meeting abstracts published in Bone 48:Suppl 2, pS97 and J Bone and Mineral Research 25:Suppl 1, pS215.
Boisse-Duplan has agreed to have any research supported by the Public Health Service — the umbrella agency of the NIH — supervised for two years, and to a two-year ban on serving on NIH peer review committees.