Chronic fatigue syndrome-XMRV paper retracted by Science, completely this time
The editors of Science have fully retracted a study they published in 2009 alleging a link between chronic fatigue syndrome (CFS) and the virus XMRV.
Science is fully retracting the Report “Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome” (1). Multiple laboratories, including those of the original authors (2), have failed to reliably detect xenotropic murine leukemia virus–related virus (XMRV) or other murine leukemia virus (MLV)–related viruses in chronic fatigue syndrome (CFS) patients. In addition, there is evidence of poor quality control in a number of specific experiments in the Report. Fig. 1, table S1, and fig. S2 have been retracted by the authors (3).
In response to concerns expressed about Fig. 2C [summarized in (4)], the authors acknowledged to Science that they omitted important information from the legend of this figure panel. Specifically, they failed to indicate that the CFS patient–derived peripheral blood mononuclear cells (PBMCs) shown in Fig. 2C had been treated with azacytidine as well as phytohemagglutinin and interleukin-2. This was in contrast to the CFS samples shown in Figs. 2A and 2B, which had not been treated with azacytidine.
The notice also makes it clear just how contentious a process it has been to sort all of this out:
Given all of these issues, Science has lost confidence in the Report and the validity of its conclusions. We note that the majority of the authors have agreed in principle to retract the Report but they have been unable to agree on the wording of their statement. It is Science’s opinion that a retraction signed by all the authors is unlikely to be forthcoming. We are therefore editorially retracting the Report. We regret the time and resources that the scientific community has devoted to unsuccessful attempts to replicate these results.
Despite the retraction, you can be sure you haven’t heard the end of this story. For one, one of the authors, Judy Mikovits, is embroiled in a legal battle with her former employer, the Whittemore Peterson Institute in Reno, Nevada, over whether she has the right to lab notebooks and other materials. She recently spent five days in a Ventura, California jail as part of the case. And she is also part of an ongoing study by Columbia University’s Ian Lipkin of 150 blood samples from people with CFS, to figure out if anything — including XMRV — can be considered a cause of the disease.
Update, 5:30 p.m. Eastern, 12/22/11: ScienceInsider has details on how the retraction came to be.
Update, 11:15 a.m. Eastern, 12/23/11: Read Ivan’s take on how Science handled the release of news of the retraction.