Expression of Concern for a Bulfone-Paus paper
Retraction Watch readers may recall the story of Silvia Bulfone-Paus, who has been forced to retract 12 papers and has another under review at Blood. All of that scrutiny came after an investigation by her home institution, Germany’s Borstel Institute, that found evidence of image manipulation.
The latest development is perhaps no surprise. It concerns a review Bulfone-Paus and her colleagues published in BioEssays in 2006. Here’s the Expression of Concern, which was published online in July but just came our attention (we’ve added links to our coverage of specific retractions):
The interleukin-15/interleukin-15 receptor system as a model for juxtacrine and reverse signaling. Silvia Bulfone-Paus, Elena Bulanova, Vadim Budagian and Ralf Paus. BioEssays 28: 362 – 377. 2006. DOI: 10.1002/bies.20380
The following papers referenced in the above review have since been retracted by the respective journals:
50. Bulanova E, Budagian V, Orinska Z, Krause H, Paus R, et al. 2003. Mast cells express novel functional interleukin-15 receptor α isoforms. J Immunol 170: 5045–5055.
52. Bulfone-Paus S, Bulanova E, Pohl T, Budagian V, Dürkop H, et al. 1999. Death deflected: IL-15 inhibits TNFα-mediated apoptosis in fibroblasts by TRAF2 recruitment to the IL-15Rα chain. FASEB J 13: 1575–1585.
54. Bulanova E, Budagian V, Pohl T, Krause H, Dürkop H, et al. 2001. The IL-15Rα chain signals through association with Syk in human B cells. J Immunol 170: 5045–5055.
55. Budagian V, Bulanova E, Orinska Z, Thon L, Mamat U, et al. 2005. A promiscuous liaison between IL-15 receptor and Axl receptor tyrosine kinase in cells death control. EMBO J 24: 4260–4270.
58. Budagian V, Bulanova E, Orinska Z, Ludwig A, Rose-John S, et al. 2004. Natural soluble interleukin-15Rα is generated by cleavage that involves the tumor necrosis factor-α-converting enzyme (TACE/ADAM17). J Biol Chem 279: 40368–40375.
92. Budagian V, Bulanova E, Orinska Z, Pohl T, Borden EC, et al. 2004. Reverse signaling through membrane-bound interleukin-15. J Biol Chem 279: 42192–42201.
The six references are among 102 in the review, which has been cited 28 times, according to Thomson Scientific’s Web of Knowledge.
Update, 9:30 p.m. Eastern, 11/9/11: BioEssays editor Andrew Moore tells us that the journal has not published Expressions of Concern before, but notes that he became editor only three years ago. Since then, the journal has not published any retractions, either. We asked him whether it should be standard practice for editors to call attention to potentially flawed reviews in situations like this:
I felt it wise to consult the Committee on Publication Ethics (COPE) in this case. The action that I took (the publication of the Expression of Concern) was the result of a consultation with COPE members in which I participated during one of the COPE forums. I believe that editors who are concerned about what to do in such a case would find it useful to consult COPE.
Hat tip: “Clare Francis”