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Retraction Watch

Tracking retractions as a window into the scientific process

Three more Bulfone-Paus retraction notices out, in Journal of Immunology

with 7 comments

Silvia Bulfone-Paus

The retraction notices for papers by Silvia Bulfone-Paus continue to appear. Yesterday, the Journal of Immunology posted notices for these three previously accepted retractions by the researcher, work at whose Borstel Centre lab is under investigation for misconduct.

We wish to retract the article titled “The IL-15Ra Chain Signals Through Association with Syk in Human B Cells” by Elena Bulanova, Vadim Budagian, Thomas Pohl, Hans Krause, Horst Du¨rkop, Ralf Paus, and Silvia Bulfone-Paus, The Journal of Immunology, 2001, 167: 6292–6302.

This retraction follows a formal investigation by the Research Center Borstel into scientific misconduct. The main findings of the investigation were the following:

1) Fig. 5B and Fig. 8A (third panel from top) are identical.
2) Fig. 8A (uppermost panel) is identical to Fig. 8B (top panel).

The first two authors declined to sign this Letter of Retraction. The key experiments of these figures were recently reproduced. Although the results confirmed the experimental data and the conclusions drawn in the publication, all the other authors retract this paper in its entirety and regret any adverse consequences that may have resulted from the paper’s publication.

We wish to retract the article titled “Mast Cells Express Novel Functional IL-15 Receptor a Isoforms” by Elena Bulanova, Vadim Budagian, Zane Orinska, Hans Krause, Ralf Paus, and Silvia Bulfone-Paus, The Journal of Immunology, 2003, 170: 5045–5055.

This retraction follows a formal investigation by the Research Center Borstel into scientific misconduct. The main findings of the investigation were the following:

1) Fig. 4A: In the middle panel (“Membrane”), a specific band (lane 2) is artificially enhanced when compared to the raw data. The raw data of Fig. 4A were also used in Fig. 9A. However, the findings of Fig. 9A were independently shown in Fig. 9C (raw data available).

2) Fig. 4B: The data shown in lanes 1, 2, and 3 of “IL-15RaD3,4,5” are identical to the data shown in lanes 1, 2, and 3 of “IL-15RaD4”.

The first two authors declined to sign this Letter of Retraction. Although recent repetitions of experiments in Fig. 4B confirm the reproducibility of the experimental data and conclusions, all the other authors retract the paper in its entirety. We deeply regret these irregularities and any adverse consequences that may have resulted from the paper’s publication and apologize to the scientific community.

We wish to retract the article titled “Extracellular ATP Induces Cytokine Expression and Apoptosis through P2X7 Receptor in Murine Mast Cells” by Elena Bulanova, Vadim Budagian, Zane Orinska, Martina Hein, Frank Petersen, Lutz Thon, Dieter Adam, and Silvia Bulfone-Paus, The Journal of Immunology, 2005, 174: 3880–3890.

This retraction follows a formal investigation by the Research Center Borstel into scientific misconduct. The main findings of the investigation were the following:

1) Fig. 3: Although in principle the reported results are correct, the error bars could not be verified on the basis of the raw data.

2) Fig. 4: The figure seems to contain several severe manipulations. Various raw data are not available. Independent repetitions of the experiments shown in Fig. 4B regarding BMMC and MC/9 (left and middle panels) confirmed the original data in principle.

The first two authors declined to sign this Letter of Retraction. All the other authors wish to retract the article. We deeply regret these irregularities and apologize to the scientific community for any inconvenience this might cause.

We have the same questions we did about yesterday’s retraction notice in EMBO Journal: Did the editors of the Journal of Immunology see evidence that the results were confirmed? And if so, do the authors plan to resubmit it to a different journal?

We have contacted the Journal of Immunology’s editor, and Bulfone-Paus, and will update with anything we hear back.

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Written by ivanoransky

February 3, 2011 at 12:17 pm

7 Responses

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  1. lOOKAT THIS! ITSNOTONLYTHE AUTHORS THAT OWE US AN APOLOGY-HOW ABOUT THE CARELESS REVIEWERS,AND THE JOURNALTHAT CHOOSES THEM.pAYING REVIEWERS AND HAVING A TRAINED CORPS OFTHEMIN VARIOUS FIELDSMIGHT HELP
    Wlaine Newman

    1) Fig. 5B and Fig. 8A (third panel from top) are identical.
    2) Fig. 8A (uppermost panel) is identical to Fig. 8B (top panel).

    elaine newman

    February 3, 2011 at 2:05 pm

  2. Did SBP ever react, also to previous inquiries?
    How about the alleged perpetrators Bulanova and Budagian?

    RM

    February 4, 2011 at 12:41 am

  3. So what happens if some of the authors refuse to sign the Letter of Retraction?

    Strigiformes

    February 7, 2011 at 11:41 pm

  4. Scand J Immunol 2002;55:484–492.

    wording of retraction published.

    http://onlinelibrary.wiley.com/doi/10.1046/j.1365-3083.2002.01081.x/abstract

    Retraction: Enhanced Inhibition of Tumour Growth
    and Metastasis, and Induction of Antitumour
    Immunity by IL-2-IgG2b Fusion Protein
    The following article from Scandinavian Journal of Immunology,
    ‘Enhanced Inhibition of Tumour Growth and
    Metastasis, and Induction of Antitumour Immunity by
    IL-2-IgG2b Fusion Protein’ by Budagian V, Nanni P,
    Lollini PL, Musiani P, Di Carlo E, Bulanova E, Paus R,
    Bulfone-Paus S, published online on 29 April 2002
    in Wiley Online Library (http://www.onlinelibrary.
    wiley.com), has been retracted by agreement between the
    corresponding ⁄ senior author, the journal Editor in Chief,
    Roland Jonsson and Blackwell Publishing, Ltd.
    The retraction has been agreed due to a finding of scientific
    misconduct within the laboratory where the experiments
    took place, and was brought to our attention by
    the scientific community.
    Reference
    1 Budagian V, Nanni P, Lollini PL, Musiani P, Di Carlo E, Bulanova
    E, Paus R, Bulfone-Paus S. Enhanced Inhibition of Tumour Growth
    and Metastasis, and Induction of Antitumour Immunity by IL-2-
    IgG2b Fusion Protein. Scand J Immunol 2002;55:484–492. Doi:
    10.1046/j.1365-3083.2002.01081.x.

    beatrice mueller

    February 9, 2011 at 10:56 am

  5. “paid reviewers”: That’s new to me. I review for a number of journals, and have never been paid. I review for the NIH, and you get a modest stipend. But not for journal reviews.

    Paul Thompson

    February 15, 2011 at 4:09 pm


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